ArticleExperimental and therapeutic medicine2017
The relationship between inflammatory mediator expression in the aqueous humor and secondary glaucoma incidence after silicone oil tamponade.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Complications of silicone oil in vitreoretinal surgery: a narrative review of clinical and experimental evidence.International journal of retina and vitreous · 2026Review
- Determinants of cataract types following pars plana vitrectomy: roles of underlying diseases, age, surgery duration, and silicone oil tamponade.BMC ophthalmology · 2026Article
- A characterization study of the anterior segment morphology of patients with and without long-term silicone oil following vitrectomy.International ophthalmology · 2025Article
- Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review).Molecular medicine reports · 2024Review
- COFrontiers in medicine · 2024Article
- Risk Factors and Management of Intraocular Pressure Elevation After Vitrectomy Combined with Silicone Oil Tamponade.International journal of general medicine · 2024Review
- Surgical Treatment in Silicone Oil-Associated Glaucoma.Diagnostics (Basel, Switzerland) · 2022Review
- Collecting and deactivating TGF-β1 hydrogel for anti-scarring therapy in post-glaucoma filtration surgery.Materials today. Bio · 2022Article
- Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review.Vision (Basel, Switzerland) · 2020Review
- The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma.International journal of molecular sciences · 2020Review
- Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation.BMC ophthalmology · 2019Article
- Inflammatory responses after vitrectomy with vitreous substitutes in a rabbit model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Analysis of the causative factors related to earlier emulsification of silicone oil.International journal of ophthalmology · 2019Article
- Long-Term Intraocular Pressure Changes after Pars Plana Vitrectomy: An 8-Year Study.Journal of current ophthalmologyArticle
- Silicone oil complications in vitreoretinal surgery.Romanian journal of ophthalmologyObservational
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of inflammatory mediators in the aqueous humor and the incidence of secondary glaucoma after vitreous body resection combined with silicone oil tamponade for patients with retinal detachment were inestigated, and the roles of IL-17, IL-6 and TNF-α in secondary glaucoma after silicone oil tamponade were analyzed. Fifty-eight cases of retinal detachment treated by vitrectomy combined with silicone oil tamponade were examined at the time of silicone oil removal surgery. All patients underwent unilateral surgery. Patients were divided into observation (19 cases with) and control (39 cases without) groups depending on development of secondary glaucoma. Prior to silicone oil removal, expression levels of IL-17, IL-6 and TNF-α in the aqueous humor were examined. IL-17, IL-6 and TNF-α levels in the aqueous humor in the observation group were 204.2±18.3, 351.1±28.4 and 850.0±51.7 pg/ml, respectively, vs. 152.3±22.2, 254.4±26.8 and 625.6±61.2 pg/ml, respectively in the control group (P<0.001). The expression of IL-17 was positively correlated with those of IL-6 and TNF-α (r=0.687, 0.745; P<0.001). IL-17, IL-6 and TNF-α presented good diagnostic values for glaucoma. The receiver operating characteristic (ROC) areas were 0.957, 0.980 and 0.975, respectively (P<0.001). The expression of inflammatory mediators such as IL-17, IL-6 and TNF-α in the aqueous humor of patients with secondary glaucoma after silicone oil tamponade significantly increased relative to patients without secondary glaucoma. The resultant inflammation may be involved in the development of secondary glaucoma.
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Registered trials
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