Evidence map›Paper›PMID 29285077›Full record

ArticleExperimental and therapeutic medicine2017

Identification of microRNAs in human circulating monocytes of postmenopausal osteoporotic Mexican-Mestizo women: A pilot study.

Rogelio F Jiménez-Ortega, Eric G Ramírez-Salazar, Alma Y Parra-Torres, Said A Muñoz-Montero, Claudia Rangel-Escareňo, Ivan Salido-Guadarrama, Mauricio Rodriguez-Dorantes, Manuel Quiterio, Jorge Salmerón, Rafael Velázquez-Cruz

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Common miRNAs of Osteoporosis and Fibromyalgia: A Review.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. A systematic review of miRNAs as biomarkers in osteoporosis disease.Journal of diabetes and metabolic disorders · 2021
    Article
  11. Article
  12. Review
  13. Deregulated miRNAs in osteoporosis: effects in bone metastasis.Cellular and molecular life sciences : CMLS · 2019
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rogelio F Jiménez-OrtegaGenetics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Eric G Ramírez-SalazarGenetics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Alma Y Parra-TorresGenetics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Said A Muñoz-MonteroComputational Genomics Consortium, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Claudia Rangel-EscareňoComputational Genomics Consortium, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Ivan Salido-GuadarramaOncogenomics Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Mauricio Rodriguez-DorantesOncogenomics Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
Manuel QuiterioCenter of Population Health Research, National Institute of Public Health (INSP), 62100 Cuernavaca-Morelos, Mexico.
Jorge SalmerónCenter of Population Health Research, National Institute of Public Health (INSP), 62100 Cuernavaca-Morelos, Mexico.
Rafael Velázquez-CruzGenetics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), 14610 Mexico City, Mexico.
National Institute of Genomic Medicine · MXInstituto Nacional de Salud Pública · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs or miRs) are a class of short non-coding RNAs that serve an important regulatory role in living organisms. These molecules are associated with multiple biological processes and are potential biomarkers in multiple diseases. The present study aimed to further identify miRNAs that are differentially expressed in circulating monocytes (CMCs) from postmenopausal Mexican-Mestizo women. Microarray analyses of monocytes using Affymetrix miRNA 4.0 and Human Genome U133 Plus 2.0 arrays were performed in 6 normal and 6 osteoporotic women, followed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) validation. The overexpression of miR-1270, miR-548×-3p and miR-8084 were detected in the osteoporosis compared with the normal group according to the microarray analysis; miR-1270, a miRNA with several target genes associated with bone remodeling, was validated by RT-qPCR. Bioinformatics analysis identified that interferon regulatory factor 8 (

Indexed as

expressionmicroRNAsmonocytesosteoclastsosteoporosis

Identifiers

PMID29285077
PMCPMC5740757
OpenAlexW2762784553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.