ArticleProceedings of the National Academy of Sciences of the United States of America2018
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site.Nature communications · 2026Article
- Forecasting Acute Hemorrhagic Conjunctivitis Incidence in Henan, China: A Comparative Study of Seasonal Autoregressive Fractionally Integrated Moving Average and Seasonal Autoregressive Integrated Moving Average Models.Risk management and healthcare policy · 2026Article
- ITAFProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The use of sialic acids as attachment factors is a common feature ofJournal of virology · 2025Article
- ICAM-1 autoantibodies detected in healthy individuals and cross-react with functional epitopes.ImmunoHorizons · 2025Article
- Coxsackievirus A24 variant associated with acute hemorrhagic conjunctivitis outbreak in Bhutan, 2023.Scientific reports · 2025Article
- Epidemiology and spatiotemporal analysis of acute hemorrhagic conjunctivitis in Zhejiang province, China (2004-2023).Frontiers in public health · 2025Article
- Characterization of enteroviruses circulating among farm animals and children in Central African Republic.Emerging microbes & infections · 2024Article
- Article
- Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells.Sub-cellular biochemistry · 2024Review
- Oncolytic virotherapy against lung cancer: key receptors and signaling pathways of viral entry.Frontiers in immunology · 2024Review
- Pathogenesis of enterovirus infection in central nervous system.Biosafety and health · 2023Review
- Apollo Rising: Acute Conjunctivitis Outbreak in India, 2022.Cornea open · 2023Article
- Article
- Construction of a Vero Cell Line Expressing Human ICAM1 for the Development of Rhinovirus Vaccines.Viruses · 2022Article
- Epidemiological trends and sociodemographic factors associated with acute hemorrhagic conjunctivitis in mainland China from 2004 to 2018.Virology journal · 2022Article
- Exploring divalent conjugates of 5-RSC advances · 2022Article
- Insights on the possibility of SARS-CoV-2 transmission through the eyes.International journal of ophthalmology · 2022Review
- Exploring the Effect of Structure-Based Scaffold Hopping on the Inhibition of Coxsackievirus A24v Transduction by Pentavalent N-Acetylneuraminic Acid Conjugates.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 5 countries.
Funding
Abstract
Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in 1970 a pathogenic "variant" (CV-A24v) emerged, which is now the main cause of AHC. Initially, this variant circulated only in Southeast Asia, but it later spread worldwide, accounting for numerous AHC outbreaks and two pandemics. While both CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for reasons that are yet unknown. Since receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoire and establish whether changes in receptor preference have led to the increased pathogenicity and rapid spread of CV-A24v. Here, we identify ICAM-1 as an essential receptor for both AHC-causing and non-AHC strains. We provide a high-resolution cryo-EM structure of a virus-ICAM-1 complex, which revealed critical ICAM-1-binding residues. These data could help identify a possible conserved mode of receptor engagement among ICAM-1-binding enteroviruses and rhinoviruses. Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptation enhances the capacity of CV-A24v to bind sialic acid. Our data elucidate the CV-A24v receptor repertoire and point to a role of enhanced receptor engagement in the adaptation to the eye, possibly enabling pandemic spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.