Evidence map›Paper›PMID 29284669›Full record

ArticleCancer discovery2018

Mark W Zimmerman, Yu Liu, Shuning He, Adam D Durbin, Brian J Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang and 5 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06502210 (Identification of New Gene Spliceosomes in Neuroblastoma and Their Translational Application in Clinical Accurate Diagnosis and Therapy), which is not on this map. Cited by 164 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06502210 unknown statusnot on this mapstarted 2024, after this paper: background citation

Identification of New Gene Spliceosomes in Neuroblastoma and Their Translational Application in Clinical Accurate Diagnosis and Therapy

Typeobservational_patient_registrySponsorAffiliated Hospital of Nantong UniversityRan2024 to 2024Enrolled20ConditionsNeuroblastomaArmsPersonalized surgical therapy of neuroblastoma
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Radiomics-Based Machine Learning for DeterminingTechnology in cancer research & treatment
    Pooled it
  2. Article
  3. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Influence ofGenome research · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Mechanisms of enhancer-driven oncogene activation.International journal of cancer · 2026
    Review
  15. Review
  16. Review
  17. Dual targeting of AMRC12 andTheranostics · 2026
    Article
  18. Article
  19. Article
  20. Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Mark W Zimmerman *Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Yu Liu *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Shuning HeDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Adam D DurbinDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Brian J AbrahamWhitehead Institute for Biomedical Research, Cambridge, Massachusetts.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ying ShaoDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Beisi XuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Shizhen ZhuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Xiaoling ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Zhaodong LiDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Nina Weichert-LeaheyDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Richard A YoungWhitehead Institute for Biomedical Research, Cambridge, Massachusetts. thomas_look@dfci.harvard.edu jinghui.zhang@stjude.org young@wi.mit.edu.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. thomas_look@dfci.harvard.edu jinghui.zhang@stjude.org young@wi.mit.edu.
A Thomas LookDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. thomas_look@dfci.harvard.edu jinghui.zhang@stjude.org young@wi.mit.edu.
Mayo Clinic · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mechanisms and Vulnerabilities of Aberrant Transcriptional Enhancers in CancerR35CA210064 · NCI · DANA-FARBER CANCER INST · PI LOOK, A. THOMAS · 2016 to 2022
$7.3M
Role of LMO1 in Neuroblastoma Initiation and MaintenanceR01CA180692 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI LOOK, A. THOMAS, MARIS, JOHN M · 2015 to 2019
$3.0M
NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA180692NCI NIH HHS R35 CA210064
6 · The paper itself

Abstract

The amplified

Indexed as

Enhancer Elements, GeneticAnimalsAnimals, Genetically ModifiedCell Line, TumorChildGene AmplificationGene Expression Regulation, NeoplasticHumansLuminescent ProteinsNeoplasms, ExperimentalNeuroblastomaN-Myc Proto-Oncogene ProteinProto-Oncogene Proteins c-mycRed Fluorescent ProteinSurvival AnalysisTranslocation, GeneticLuminescent ProteinsMYCN protein, humanMYC protein, humanN-Myc Proto-Oncogene ProteinProto-Oncogene Proteins c-mycRed Fluorescent Protein

Identifiers

PMID29284669
PMCPMC5856009
OpenAlexW2777333782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.