ArticleAJNR. American journal of neuroradiology2018
Cervical Cord Atrophy and Long-Term Disease Progression in Patients with Primary-Progressive Multiple Sclerosis.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Clinical course of critical demyelinating lesion-associated progressive multiple sclerosis.Journal of neurology · 2026Article
- Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis.Annals of clinical and translational neurology · 2025Article
- Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis.The Lancet regional health. Europe · 2024Review
- Magnetic Resonance Imaging in Primary Progressive Multiple Sclerosis Patients : Review.Clinical neuroradiology · 2022Review
- Cervical and thoracic cord atrophy in multiple sclerosis phenotypes: Quantification and correlation with clinical disability.NeuroImage. Clinical · 2021Article
- Magnetic resonance imaging in immune-mediated myelopathies.Journal of neurology · 2020Review
- Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI.NeuroImage. Clinical · 2020Article
- Evaluation of Intra- and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross-Sectional Area Measurements.Journal of magnetic resonance imaging : JMRI · 2019Article
- Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
- Magnetic resonance imaging correlates of neuro-axonal pathology in the MS spinal cord.Brain pathology (Zurich, Switzerland) · 2018Review
- Future Brain and Spinal Cord Volumetric Imaging in the Clinic for Monitoring Treatment Response in MS.Current treatment options in neurology · 2018Review
- Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCervical cord atrophy has been associated with clinical disability in multiple sclerosis and is proposed as an outcome measure of neurodegeneration. The aim of this study was to quantify the development of cervical cord atrophy and to evaluate its association with disability progression in patients with primary-progressive multiple sclerosis. MATERIALS AND
methodsThirty-one patients with primary-progressive multiple sclerosis underwent 1.5T brain and spinal cord MR imaging at baseline and 6-7 years later. The cervical spinal cord from C1 to C5 was segmented to evaluate the normalized overall cross-sectional area and the cross-sectional area of C2-C3, C3-C4, and C4-C5. The annualized rates of normalized cross-sectional area loss were also evaluated. To estimate clinical progression, we determined the Expanded Disability Status Scale score at baseline and at 2 and 14 years after baseline to compute the normalized area under the curve of the Expanded Disability Status Scale and the Expanded Disability Status Scale changes from baseline to the follow-up time points. Associations between the cord cross-sectional area and brain MR imaging and clinical measures were also investigated. Finally, the value of all these measures for predicting long-term disability was evaluated.
resultsSome normalized cross-sectional area measurements showed moderate correlations with the normalized area under the curve of the Expanded Disability Status Scale, ranging from -0.439 to -0.359 (
conclusionsThese data indicate that development of cervical cord atrophy is associated with progression of disability and is predictive of this event in patients with primary-progressive MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.