ArticleMalaria journal2017
Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal.
Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Malaria misdiagnosis among febrile patients in Senegal: implications for the underestimation of Plasmodium species diversity and malaria burden.Malaria journal · 2026Article
- Common Molecular Detection of the Neglected Human Malaria Parasite Among Febrile Patients in Southern Regions in Senegal.Pathogens (Basel, Switzerland) · 2025Article
- Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal.Parasites & vectors · 2025Article
- Circulation of non-falciparum malaria species in West Africa: A literature review from 2000 to 2024.MalariaWorld journal · 2025Review
- Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal.medRxiv : the preprint server for health sciences · 2024Article
- Variable effects of non-falciparum species infections on malaria disease severity in high transmission regions in Senegal.Tropical medicine and health · 2024Article
- Evidence of Plasmodium vivax circulation in western and eastern regions of Senegal: implications for malaria control.Malaria journal · 2024Article
- Molecular speciation of Plasmodium and multiplicity of P. falciparum infection in the Central region of Ghana.PLOS global public health · 2024Article
- Malaria Elimination in Africa: Rethinking Strategies forTropical medicine and infectious disease · 2023Review
- Using Serological Markers for the Surveillance ofPathogens (Basel, Switzerland) · 2023Article
- Performance of a Commercial Multiplex Allele-Specific Polymerase Chain Reaction Kit to Genotype African-Type Glucose-6-Phosphate Dehydrogenase Deficiency.The American journal of tropical medicine and hygiene · 2023Article
- Molecular detection and quantification ofFrontiers in parasitology · 2023Article
- Spatial cluster analysis of Plasmodium vivax and P. malariae exposure using serological data among Haitian school children sampled between 2014 and 2016.PLoS neglected tropical diseases · 2022Article
- The global burden of Plasmodium vivax malaria is obscure and insidious.PLoS medicine · 2021Article
- Basic Research ofFrontiers in cellular and infection microbiology · 2021Review
- Multi-locus genotyping reveals established endemicity of a geographically distinct Plasmodium vivax population in Mauritania, West Africa.PLoS neglected tropical diseases · 2020Article
- Presence of additional Plasmodium vivax malaria in Duffy negative individuals from Southwestern Nigeria.Malaria journal · 2020Article
- Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure.Malaria journal · 2020Article
- Large Variations in Malaria Parasite Carriage by Afebrile School Children Living in Nearby Communities in the Central Region of Ghana.Journal of tropical medicine · 2020Article
- Ribosomal and non-ribosomal PCR targets for the detection of low-density and mixed malaria infections.Malaria journal · 2019Article
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundMalaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has been recently reported in the region of Kedougou, raising the question of appraisal of its potential prevalence in this setting.
methodsA retrospective serological study was carried out using 188 samples taken from 2010 to 2011 in a longitudinal school survey during which 48 asymptomatic children (9-11 years) were recruited. Four collections of samples collected during two successive dry and rainy seasons were analysed for antibody responses to P. vivax and P. falciparum. Recombinant P. falciparum and P. vivax MSP1 antigens and total P. falciparum schizont lysate from African 07/03 strain (adapted to culture) were used for ELISA. Nested PCR amplification was used for molecular detection of P. vivax.
resultsA surprising high prevalence of IgG responses against P. vivax MSP1 was evidenced with 53% of positive samples and 58% of the individuals that were found positive to this antigen. There was 77% of responders to P. falciparum outlined by 63% of positive samples. Prevalence of responders did not differ as function of seasons. Levels of antibodies to P. falciparum fluctuated with significant increasing between dry and rainy season (P < 0.05), contrary to responses to P. vivax. There was a significant reciprocal relationship (P < 10
conclusionThis cross-sectional longitudinal study highlights the unexpected high circulation of P. vivax in this endemic area. Sero-immunology and molecular methods are powerful additive tools to identify endemic sites where relevant control measures have to be settled and monitored.
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