ArticleMalaria journal2017
Why some sites are responding better to anti-malarial interventions? A case study from western Kenya.
Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A systematic review of changing malaria disease burden in sub-Saharan Africa since 2000: comparing model predictions and empirical observations.BMC medicine · 2020Pooled it
- Mapping Potential Malaria Vector Larval Habitats for Larval Source Management in Western Kenya: Introduction to Multimodel Ensembling Approaches.The American journal of tropical medicine and hygiene · 2024Article
- A prospective cohort study of Plasmodium falciparum malaria in three sites of Western Kenya.Parasites & vectors · 2022Article
- Irrigation-Induced Environmental Changes Sustain Malaria Transmission and Compromise Intervention Effectiveness.The Journal of infectious diseases · 2022Article
- Malaria epidemic and transmission foci in highland of Kisii, western Kenya.Parasite epidemiology and control · 2022Article
- Assessment of knowledge of malaria and its control practices in mining and sugarcane growing regions of Western Kenya highlands.African health sciences · 2022Article
- Behavioural plasticity of Anopheles coluzzii and Anopheles arabiensis undermines LLIN community protective effect in a Sudanese-savannah village in Burkina Faso.Parasites & vectors · 2020Article
- Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya.Malaria journal · 2018Article
- The current malaria morbidity and mortality in different transmission settings in Western Kenya.PloS one · 2018Article
- Utility of passive malaria surveillance in hospitals as a surrogate to community infection transmission dynamics in western Kenya.Archives of public health = Archives belges de sante publique · 2018Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIn sub-Saharan Africa, malaria interventions over the last decades have been successful in reducing both mortality and morbidity. In western Kenya however some areas experience contrasting outcomes of the ongoing interventions while the causes for this observation remains not yet clearly known.
methodsThe WHO insecticide (deltamethrin) susceptibility test of the common malaria vectors was studied. Multiple surveys on household use and hospital prescriptions of antimalarial drugs from 2003 to 2015 were done. Along with this, cross sectional surveys on their availability in the local drug dispensing outlets were also done in 2015. Monthly precipitations and air temperature data was collected along with systematic review on abundance and composition of common malaria vectors in the study area before and during interventions. The above factors were used to explain the possible causes of contrasting outcome of malaria interventions between the three study sites.
resultsAreas with malaria resurgence or sustained high transmission (Kombewa and Marani) showed higher composition of Anopheles funestus sensu lato (s.l.) than the previously abundant Anopheles gambiae sensu stricto (s.s.) and the later had higher composition to an area with a sustained infection decline (Iguhu). Anopheles gambiae s.l. from Kombewa showed highest resistance (50% mortality) upon exposure to WHO deltamethrin discriminating dosage of 0.75% while those from Marani and Iguhu had reduced resistance status (both had a mean mortality of 91%). Sampled An. funestus s.l. from Marani were also highly resistant to deltamethrin as 57% of the exposed vectors survived. An increasing of mean air temperature by 2 °C was noted for Marani and Iguhu from 2013 to 2015 and was accompanied by an increased rainfall at Marani. Community drug use and availability in selling outlets along with prescription in hospitals were not linked to the struggling control of the disease.
conclusionsThe malaria vector species composition shift, insecticide resistance and climatic warming were the likely cause of the contrasting outcome of malaria intervention in western Kenya. Surveillance of malaria parasite and vector dynamics along with insecticide resistance and vector biting behaviour monitoring are highly recommended in these areas.
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