ArticleBMC infectious diseases2017
The aetiologies of central nervous system infections in hospitalised Cambodian children.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Diagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in cerebrospinal fluid in pediatric patients with central nervous system infection: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Report of two severe cases of Japanese encephalitis virus in travelers returning to France, 2023-2024: clinical, diagnostic, and public health implications.ASM case reports · 2025Article
- Pentraxin 3: a novel biomarker in pediatric central nervous system infections.BMC pediatrics · 2025Article
- Central nervous system infection in a pediatric population in West Java.PLoS neglected tropical diseases · 2023Article
- Epidemiological and clinical characteristics of central nervous system infections in a tertiary center: A retrospective study.Health science reports · 2023Article
- Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles.Frontiers in public health · 2023Article
- Outbreak of central nervous system infections among children in Thai Binh, Viet Nam.Emerging microbes & infections · 2022Article
- Modelling Japanese encephalitis virus transmission dynamics and human exposure in a Cambodian rural multi-host system.PLoS neglected tropical diseases · 2022Article
- Spatial epidemiology of Japanese encephalitis virus and other infections of the central nervous system infections in Lao PDR (2003-2011): A retrospective analysis.PLoS neglected tropical diseases · 2020Article
- High diversity of mosquito vectors in Cambodian primary schools and consequences for arbovirus transmission.PloS one · 2020Article
- Serological Evidence for Japanese Encephalitis and West Nile Virus Infections in Domestic Birds in Cambodia.Frontiers in veterinary science · 2020Article
- Flaviviruses as agents of childhood central nervous system infections in Brazil.New microbes and new infections · 2019Review
- Flaviviruses as agents of childhood central nervous system infections in Brazil.New microbes and new infections · 2019Article
- Metagenome Analysis as a Tool to Study Bacterial Infection Associated with Acute Surgical Abdomen.Journal of clinical medicine · 2018Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
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Abstract
backgroundCentral nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia.
methodsWe did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens. Viral metagenomics was performed on a subset of pathogen negative specimens.
resultsBetween 1st October 2014 and 30th September 2015, 284 analysable patients were enrolled. The median patient age was 2.6 years; 62.0% were aged <5 years. CSF white blood cell count was ≥10 cells/μL in 116/272 (42.6%) cases. CNS infection was microbiologically confirmed in 55 children (19.3%). Enteroviruses (21/55), Japanese encephalitis virus (17/55), and Streptococcus pneumoniae (7/55) accounted for 45 (81.8%) of all pathogens identified. Of the pathogens detected, 74.5% (41/55) were viruses and 23.6% (13/55) were bacteria. The majority of patients were treated with ceftriaxone empirically. The case fatality rate was 2.5%.
conclusionsEnteroviruses, JEV and S. pneumoniae are the most frequently detected causes of CNS infection in hospitalised Cambodian children.
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