ArticlePLoS biology2017
A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Salt glands in exo-recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance.Journal of integrative plant biology · 2026Review
- Warming outweighs nitrogen deposition in shaping rhizosphere microbial structure involved in carbon, nitrogen, and phosphorus cycling inFrontiers in plant science · 2026Article
- Panoramic Research onInternational journal of molecular sciences · 2025Review
- A pectin acetyl-transferase facilitates secondary plasmodesmata formation and RNA silencing movement between plant cells.The Plant journal : for cell and molecular biology · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Manganese handling in plants: Advances in the mechanistic and functional understanding of transport pathways.Quantitative plant biology · 2025Review
- Advances in understanding the graft healing mechanism: a review of factors and regulatory pathways.Horticulture research · 2024Article
- Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate.Nature communications · 2023Article
- Endoplasmic reticulum stress controls PIN-LIKES abundance and thereby growth adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Promotive Role of 5-Aminolevulinic Acid or Salicylic Acid Combined with Citric Acid on Sunflower Growth by Regulating Manganese Absorption.Antioxidants (Basel, Switzerland) · 2023Article
- Multilayered regulation of iron homeostasis in Arabidopsis.Frontiers in plant science · 2023Review
- Effects of Fe and Mn Deficiencies on the Root Protein Profiles of Tomato (International journal of molecular sciences · 2022Article
- Proteomics and Co-expression Network Analysis Reveal the Importance of Hub Proteins and Metabolic Pathways in Nicotine Synthesis and Accumulation in Tobacco (Frontiers in plant science · 2022Article
- ZmCTLP1 is required for the maintenance of lipid homeostasis and the basal endosperm transfer layer in maize kernels.The New phytologist · 2021Article
- NPF transporters in synaptic-like vesicles control delivery of iron and copper to seeds.Science advances · 2021Article
- A high-quality genome assembly and annotation of the gray mangrove, Avicennia marina.G3 (Bethesda, Md.) · 2021Article
- A curated list of genes that affect the plant ionome.Plant direct · 2020Article
- UV-B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development.The EMBO journal · 2020Article
- Manganese in Plants: From Acquisition to Subcellular Allocation.Frontiers in plant science · 2020Review
- Dynamic regulation of plasmodesmatal permeability and its application to horticultural research.Horticulture research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.