ArticlePLoS biology2017
Alternative therapeutics for self-limiting infections-An indirect approach to the antibiotic resistance challenge.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Evaluation of preoperative antibiotic prophylaxis in clean-wound general surgery procedures: a propensity score-matched cohort study at a regional hospital.BMC surgery · 2024Article
- Public health case for microbiome-sparing antibiotics and new opportunities for drug development.mSphere · 2024Article
- Review
- Phage Therapies: Lessons (Not) Learned from the "Antibiotic Era".PHAGE (New Rochelle, N.Y.) · 2022Article
- Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2021Article
- Proliferation and benevolence-A framework for dissecting the mechanisms of microbial virulence and health promotion.Evolutionary applications · 2020Article
- Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels.PLoS computational biology · 2019Article
- Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation.PLoS biology · 2019Article
- Community interactions and spatial structure shape selection on antibiotic resistant lineages.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternative therapeutics for infectious diseases is a top priority, but what infections should be the primary targets? At present there is a focus on therapies for severe infections, for which effective treatment is most needed, but these infections are hard to manage, and progress has been limited. Here, we explore a different approach. Applying an evolutionary perspective to a review of antibiotic prescription studies, we identify infections that likely make a large contribution to resistance evolution across multiple taxa but are clinically mild and thus present easier targets for therapeutics development. Alternative therapeutics for these infections, we argue, would save lives indirectly by preserving the high efficacy of existing antibiotics for the patients who need them the most.
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Registered trials
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