ArticlePLoS biology2017
Arabidopsis choline transporter-like 1 (CTL1) regulates secretory trafficking of auxin transporters to control seedling growth.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes.Life science alliance · 2026Article
- Artificial Intelligence Powered Wearable and Portable Devices for Remote Cardiac Care and Population Health.Current cardiology reports · 2026Review
- Comprehensive genomic and phenotypic analyses reveal the genetic basis of fruit quality in litchi.Genome biology · 2025Article
- Multiple, Single Trait GWAS and Supervised Machine Learning Reveal the Genetic Architecture of Fraxinus excelsior Tolerance to Ash Dieback in Europe.Plant, cell & environment · 2025Article
- Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate.Nature communications · 2023Article
- Endoplasmic reticulum stress controls PIN-LIKES abundance and thereby growth adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Plant elicitor peptide induces endocytosis of plasma membrane proteins in Arabidopsis.Frontiers in plant science · 2023Article
- Salicylic Acid Regulates Root Gravitropic Growth via Clathrin-Independent Endocytic Trafficking of PIN2 Auxin Transporter inInternational journal of molecular sciences · 2022Article
- Subcellular trafficking and post-translational modification regulate PIN polarity in plants.Frontiers in plant science · 2022Review
- ZmCTLP1 is required for the maintenance of lipid homeostasis and the basal endosperm transfer layer in maize kernels.The New phytologist · 2021Article
- The microtubule-associated protein WDL4 modulates auxin distribution to promote apical hook opening in Arabidopsis.The Plant cell · 2021Article
- Endosidin2-14 Targets the Exocyst Complex in Plants and Fungal Pathogens to Inhibit Exocytosis.Plant physiology · 2019Article
- Transcriptomic Responses to Thermal Stress and Varied Phosphorus Conditions inMicroorganisms · 2019Article
- Sieve Plate Pores in the Phloem and the Unknowns of Their Formation.Plants (Basel, Switzerland) · 2019Review
- Transmembrane transport and stress response genes play an important role in adaptation of Arabidopsis halleri to metalliferous soils.Scientific reports · 2018Article
- The PIN-FORMED Auxin Efflux Carriers in Plants.International journal of molecular sciences · 2018Review
- Functional Analysis of theInternational journal of molecular sciences · 2018Article
- Heat stress induces spikelet sterility in rice at anthesis through inhibition of pollen tube elongation interfering with auxin homeostasis in pollinated pistils.Rice (New York, N.Y.) · 2018Article
- Lipids at the crossroad: Shaping biological membranes heterogeneity defines trafficking pathways.PLoS biology · 2018Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin controls a myriad of plant developmental processes and plant response to environmental conditions. Precise trafficking of auxin transporters is essential for auxin homeostasis in plants. Here, we report characterization of Arabidopsis CTL1, which controls seedling growth and apical hook development by regulating intracellular trafficking of PIN-type auxin transporters. The CTL1 gene encodes a choline transporter-like protein with an expression pattern highly correlated with auxin distribution and is enriched in shoot and root apical meristems, lateral root primordia, the vascular system, and the concave side of the apical hook. The choline transporter-like 1 (CTL1) protein is localized to the trans-Golgi network (TGN), prevacuolar compartment (PVC), and plasma membrane (PM). Disruption of CTL1 gene expression alters the trafficking of 2 auxin efflux transporters-Arabidopsis PM-located auxin efflux transporter PIN-formed 1 (PIN1) and Arabidopsis PM-located auxin efflux transporter PIN-formed 3 (PIN3)-to the PM, thereby affecting auxin distribution and plant growth and development. We further found that phospholipids, sphingolipids, and other membrane lipids were significantly altered in the ctl1 mutant, linking CTL1 function to lipid homeostasis. We propose that CTL1 regulates protein sorting from the TGN to the PM through its function in lipid homeostasis.
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