ReviewCurrent opinion in gastroenterology2018
An update on the pathogenesis of cholesterol gallstone disease.
Review in Current opinion in gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Pooled it
- Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis.Lipids in health and disease · 2023Pooled it
- Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.Frontiers in endocrinology · 2022Pooled it
- Fruits and vegetables consumption and the risk of gallstone diasease: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Trial
- The biliary microbiome in symptomatic cholelithiasis: a prospective comparison across distinct bacterial niches.BMC microbiology · 2026Observational
- The association between dietary protein and gallstones in adults under 60 years old: A cross-sectional study.Medicine · 2026Article
- Article
- Article
- Bempedoic acid within the phase ternary diagram governing biliary cholesterol solubilization and gallstone risk.Journal of lipid research · 2026Review
- Multi-center Study of the Association Between Serum Lipid Levels and Recurrent Common Bile Duct Stone After Endoscopic Retrograde Cholangiopancreatography with Propensity Score Matching Analysis.Digestive diseases and sciences · 2026Article
- Dietary fiber intake and gallstones: The mediating role of serum lipids.The Journal of international medical research · 2026Article
- Article
- Article
- Veillonella, Neisseria, Prevotella, and Lachnoanaerobaculum enrichment in salivary microbiome predicts gallstone disease.European journal of medical research · 2026Article
- Review
- Article
- Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cross-sectional associations of lipid accumulation and immune-nutritional indices with ultrasonography-detected gallstone disease: an explainable machine learning analysis.Frontiers in nutrition · 2026Article
- Cross-population heterogeneity in the association between estimated sdLDL-C and gallstone disease: a dual-source two-sample cross-sectional study.Frontiers in public health · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purpose of reviewGallstone disease is a major epidemiologic and economic burden worldwide, and the most frequent form is cholesterol gallstone disease. RECENT
findingsMajor pathogenetic factors for cholesterol gallstones include a genetic background, hepatic hypersecretion of cholesterol, and supersaturated bile which give life to precipitating cholesterol crystals that accumulate and grow in a sluggish gallbladder. Additional factors include mucin and inflammatory changes in the gallbladder, slow intestinal motility, increased intestinal absorption of cholesterol, and altered gut microbiota. Mechanisms of disease are linked with insulin resistance, obesity, the metabolic syndrome, and type 2 diabetes. The role of nuclear receptors, signaling pathways, gut microbiota, and epigenome are being actively investigated. SUMMARY: Ongoing research on cholesterol gallstone disease is intensively investigating several pathogenic mechanisms, associated metabolic disorders, new therapeutic approaches, and novel strategies for primary prevention, including lifestyles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.