Evidence map›Paper›PMID 29283498›Full record

ArticleGenes, brain, and behavior2018

Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior.

R J Oliver, J L Brigman, F Bolognani, A M Allan, J L Neisewander, N I Perrone-Bizzozero

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Circular RNA regulation and function in drug seeking phenotypes.Molecular and cellular neurosciences · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Protein Translation and Psychiatric Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

R J OliverDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico.
J L BrigmanDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico.
F BolognaniRoche Pharma Research and Early Development; Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center, Basel, Switzerland.
A M AllanDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico.
J L NeisewanderSchool of Life Sciences, Arizona State University, Tempe, Arizona.
N I Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico.ORCID 0000-0002-7608-1332
University of New Mexico · USArizona State University · USRoche (Switzerland) · CH

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BOYCE, ANDREW · 2015 to 2024
$22.7M
Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Destabilization of axonal mRNAs by KHSRP complexes during axon regenerationR01NS089633 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2015 to 2025
$4.1M
Alcohol Research Training in NeurosciencesT32AA014127 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jonathan L Brigman · 2003 to 2026
$3.3M
Mechanisms of Post-Transcriptional Control of Neuronal mRNAsR01NS030255 · NINDS · UNIVERSITY OF NEW MEXICO · PI PERRONE-BIZZOZERO, NORA IRMA · 1997 to 2011
$2.8M
Competing roles of microRNAs and RNA-binding proteins in drug addictionR01DA034097 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NEISEWANDER, JANET L, PERRONE-BIZZOZERO, NORA IRMA · 2012 to 2016
$2.2M
Corticostriatal networks and NMDAR mediation of habitual and flexible actionK22AA020303 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRIGMAN, JONATHAN L · 2011 to 2013
$486k
Opposing roles of miR-495 and HuD in addiction-related plasticity and behaviorF31DA041214 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI OLIVER, ROBERT JOHN · 2016 to 2017
$54k
NIAAA NIH HHS K22 AA020303NIAAA NIH HHS P50 AA022534NIAAA NIH HHS T32 AA014127NIDA NIH HHS F31 DA041214NIDA NIH HHS R01 DA034097NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS030255NINDS NIH HHS R01 NS089633
6 · The paper itself

Abstract

The neuronal RNA-binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD-mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuD

Indexed as

3' Untranslated RegionsAnimalsBehavior, AddictiveBehavior, AnimalBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2CocaineCocaine-Related DisordersConditioning, PsychologicalELAV-Like Protein 4Gene ExpressionMaleMiceMice, Inbred C57BLMice, TransgenicNeurons3' Untranslated RegionsBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseCocaineElavl4 protein, mouseELAV-Like Protein 4RNA, MessengerBDNFCaMKIIαCPPHuDnucleus accumbenspost-transcriptional regulationRNA-binding protein

Identifiers

PMID29283498
PMCPMC5903947
OpenAlexW2779557694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.