Evidence map›Paper›PMID 29283422›Full record

ArticleInternational journal of molecular sciences2017

Hyperglycemia Augments the Adipogenic Transdifferentiation Potential of Tenocytes and Is Alleviated by Cyclic Mechanical Stretch.

Yu-Fu Wu, Yu-Ting Huang, Hsing-Kuo Wang, Chung-Chen Jane Yao, Jui-Sheng Sun, Yuan-Hung Chao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  6. Animal model for tendinopathy.Journal of orthopaedic translation · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yu-Fu WuSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. Jay5300@gmail.com.
Yu-Ting HuangSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. r05428002@ntu.edu.tw.
Hsing-Kuo WangSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. hkwang@ntu.edu.tw.
Chung-Chen Jane YaoGraduate Institute of Clinical Dentistry and Department of Dentistry, School of Dentistry, National Taiwan University, Taipei 10048, Taiwan. janeyao@ntu.edu.tw.
Jui-Sheng SunDepartment of Orthopedic Surgery, College of Medicine, National Taiwan University, Taipei 10051, Taiwan. drjssun@ntuh.gov.tw.
Yuan-Hung ChaoSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. yuanhungchao@ntu.edu.tw.
National Taiwan University Hospital · TWNational Taiwan University · TWUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is associated with damage to tendons, which may result from cellular dysfunction in response to a hyperglycemic environment. Tenocytes express diminished levels of tendon-associated genes under hyperglycemic conditions. In contrast, mechanical stretch enhances tenogenic differentiation. However, whether hyperglycemia increases the non-tenogenic differentiation potential of tenocytes and whether this can be mitigated by mechanical stretch remains elusive. We explored the in vitro effects of high glucose and mechanical stretch on rat primary tenocytes. Specifically, non-tenogenic gene expression, adipogenic potential, cell migration rate, filamentous actin expression, and the activation of signaling pathways were analyzed in tenocytes treated with high glucose, followed by the presence or absence of mechanical stretch. We analyzed tenocyte phenotype in vivo by immunohistochemistry using an STZ (streptozotocin)-induced long-term diabetic mouse model. High glucose-treated tenocytes expressed higher levels of the adipogenic transcription factors

Indexed as

Stress, MechanicalAdipocytesAdipogenesisAnimalsBiomechanical PhenomenaCCAAT-Enhancer-Binding Protein-betaCell TransdifferentiationDiabetes Mellitus, ExperimentalGene Expression RegulationGlucoseMaleMechanotransduction, CellularMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PPAR gammaCCAAT-Enhancer-Binding Protein-betaCebpb protein, ratGlucoseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PPAR gammaProto-Oncogene Proteins c-aktStreptozocindiabetesdifferentiationglucosemechanical stretchPPARγtendon

Identifiers

PMID29283422
PMCPMC5796040
OpenAlexW2777182833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.