ArticleeLife2017
Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026Review
- Article
- Fission-independent compartmentalization of mitochondria during budding yeast cell division.The Journal of cell biology · 2024Article
- Comparative analysis of genome-wide transcriptional responses to continuous heat stress in Pleurotus tuoliensis.AMB Express · 2023Article
- Septin Defects Favour Symmetric Inheritance of the Budding Yeast Deceptive Courtship Memory.International journal of molecular sciences · 2023Article
- Lack of peroxisomal catalase affects heat shock response inLife science alliance · 2023Article
- DNA circles promote yeast ageing in part through stimulating the reorganization of nuclear pore complexes.eLife · 2022Article
- Telomeric C-circles localize at nuclear pore complexes in Saccharomyces cerevisiae.The EMBO journal · 2022Article
- Modeling aging and its impact on cellular function and organismal behavior.Experimental gerontology · 2021Review
- Cosegregation of asymmetric features during cell division.Open biology · 2021Article
- Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.Nature communications · 2021Article
- Mapping bilayer thickness in the ER membrane.Science advances · 2020Article
- The adaptive potential of circular DNA accumulation in ageing cells.Current genetics · 2020Review
- Asymmetric cell division and replicative aging: a new perspective from the spindle poles.Current genetics · 2020Review
- The Fate of Lipid-Coated and Uncoated Fluorescent Nanodiamonds during Cell Division in Yeast.Nanomaterials (Basel, Switzerland) · 2020Article
- The TOR Pathway Plays Pleiotropic Roles in Growth and Stress Responses of the Fungal PathogenGenetics · 2019Article
- Article
- Autonomously Replicating Linear Plasmids That Facilitate the Analysis of Replication Origin Function inmSphere · 2019Article
- Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling.Aging · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although individuals of many species inexorably age, a number of observations established that the rate of aging is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of DNA circles, which act as aging factors in the mother cell. The enhanced frequency at which circles redistribute to daughter cells was not due to changes of anaphase duration or nuclear shape but solely to the downregulation of the diffusion barrier in the nuclear envelope. This effect depended on the PKA and Tor1 pathways, downstream of stress-response kinase Pkc1. Inhibition of these responses restored barrier function and circle retention and abrogated the effect of heat stress on longevity. Our data indicate that redistribution of aging factors from aged cells to their progeny can be a mechanism for modulating longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.