ArticleIndian journal of ophthalmology2018
Retinal nerve fiber layer and ganglion cell layer changes on optical coherence tomography in early multiple sclerosis and optic neuritis cases.
Article in Indian journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Consensus statement for the diagnosis and management of optic neuritis.Indian journal of ophthalmology · 2026Review
- Association of Peripapillary Retinal Nerve Fibre Layer Thickness with Disability and MRI Findings in Multiple Sclerosis: A Retrospective Single-Centre Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Longitudinal Assessment of Ocular Biomarkers in Individuals With Gulf War Illness Symptoms.Military medicine · 2025Article
- Article
- Visual impairment and retinal and brain neurodegeneration: A population-based study.Human brain mapping · 2023Article
- Serum Neurofilaments and OCT Metrics Predict EDSS-Plus Score Progression in Early Relapse-Remitting Multiple Sclerosis.Biomedicines · 2023Article
- Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients.International journal of ophthalmology · 2022Article
- Approach to optic neuritis: An update.Indian journal of ophthalmology · 2021Review
- Assessment of central retinal thickness, choroidal thickness, and retinal nerve fiber layer in psoriasis: a spectral-domain optical coherence tomography study.BMC ophthalmology · 2021Article
- Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up.Neurology research international · 2021Article
- Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury.JAMA network open · 2020Article
- Article
- Multiple Sclerosis in India.Annals of Indian Academy of NeurologyArticle
- Regional retinal vulnerability in multiple sclerosis: integrating OCT, MRI, and clinical data for enhanced diagnosis and automated monitoring.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Deep Learning and The Retina: A New Frontier in Multiple Sclerosis Diagnosis.Current health sciences journalReview
- Inner retinal thickness and optic disc measurements in obese children and adolescents.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) changes on optical coherence tomography in early multiple sclerosis (MS) patients.
methodsA prospective cohort study was conducted at a tertiary care center. Patients of early MS (expanded disability status scale <3) with or without optic neuritis (ON) and idiopathic ON were included. Twenty age-matched individuals were taken as controls. Changes in RNFL and GCL thickness were evaluated along with the correlation with visual function parameters such as visual acuity, contrast sensitivity, and visual evoked response at first visit and again at six months.
resultsForty-four patients of MS with or without ON (24 and 20 patients respectively), 29 patients with idiopathic ON, and 20 healthy controls constituted the cohorts. Mean LogMAR best-corrected visual acuity was found to be significantly reduced in all groups except fellow eyes (FE) of ON group. Mean values of average RNFL thickness and values in superior, temporal, and inferior quadrant were significantly reduced. Similarly, overall mean values of average GCL-inner plexiform layer (IPL) thickness and values in superior, superonasal, superotemporal, inferonasal, and inferotemporal quadrant were significantly reduced in all groups except FE of ON group (P < 0.05). All the visual parameters significantly correlated with GCL + IPL thickness.
conclusionGCL + IPL thickness is a more sensitive clinical structural marker than RNFL in early MS with/without ON and ON patients and correlates with all the visual parameters better than RNFL thickness.
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