Evidence map›Paper›PMID 29282872›Full record

ArticleEarly intervention in psychiatry2018

Psychotic-spectrum symptoms, cumulative adversity exposure and substance use among high-risk girls.

Amy E Lansing, Wendy Y Plante, Christine Fennema-Notestine, Shahrokh Golshan, Audrey N Beck

Open access · greenAbstract read
In one paragraph

Article in Early intervention in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amy E LansingDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Wendy Y PlanteDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Christine Fennema-NotestineDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Shahrokh GolshanDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Audrey N BeckDepartment of Sociology, San Diego State University, San Diego, California.
San Diego State University · USUniversity of California, San Diego · US

Funding

San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
Testing a Comorbid PTSD & Substance/Alcohol Use Intervention in Delinquent GirlsR01HD066161 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANSING, AMY E · 2010 to 2014
$2.4M
Neural Mechanisms Subserving Deficits in High-Risk YouthK01HD051112 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANSING, AMY E · 2006 to 2010
$803k
NCATS NIH HHS UL1 TR000100NCRR NIH HHS UL1 RR031980NICHD NIH HHS K01 HD051112NICHD NIH HHS R01 HD066161
6 · The paper itself

Abstract

aimPsychotic-spectrum symptoms are linked to trauma, substance/alcohol use (SAU), criminality/violence and poor functional outcomes, supporting the need for early detection in vulnerable populations. To better understand high-risk girls' mental health, we assessed: (1) psychotic-spectrum symptoms; (2) cumulative trauma, adversity and loss exposures (C-TALE) and adversity-indicators (symptoms, maladaptive coping, stressor-reactivity); and SAU risk-factors; and (3) relationships among psychotic-spectrum symptoms, adversity-indicators and SAU risk-factors.

methodsWe administered the Structured Clinical Interviews for Psychotic Spectrum, and Trauma and Loss Spectrum to 158 adolescent delinquent girls.

resultsGirls' psychotic-spectrum profiles were similar to previously reported adult psychotic patients and characterized by typical symptoms (hallucinations/delusions, reported largely SAU-independent), interpersonal sensitivity, schizoid traits and paranoia (over-interpretation, anger over-reactivity, hypervigilance). Auditory/visual hallucinations (55.7%), delusions (92.4%), ideas of reference (96.8%) and adversity (90.0% ≥10/24 C-TALE-types) were common. Mean loss (4) and trauma (8) onset-age occurred before SAU-onset (12). Significant positive correlations were found among psychotic-spectrum symptoms, stressor-reactivity, C-TALE, adversity-indicators; and number of SAU-types; and a negative correlation occurred between psychotic-spectrum symptoms and earlier alcohol use onset. After controlling for number of SAU-types, stressor-reactivity and adversity-related numbing individually had the largest associations with total psychotic-spectrum symptoms (b = 2.6-4.3). Girls averaged more than 4 maladaptive coping strategies (e.g., 24.8% attempted suicide) in response to adversity, amplifying potential health-disparities. No racial/ethnic differences emerged on psychotic-spectrum symptoms.

conclusionsThis symptom constellation during adolescence likely interferes with social and academic functioning. Whether representing a prodromal phase, trauma-response or cross-diagnostic psychopathology, accurate early detection and appropriate treatment of psychotic-spectrum symptoms are warranted to improve functional outcomes in vulnerable populations.

Indexed as

Life Change EventsAdaptation, PsychologicalAdolescentAdolescent BehaviorDelusionsFemaleHallucinationsHumansJuvenile DelinquencyPsychotic DisordersRisk FactorsSubstance-Related DisordersViolenceVulnerable Populationscumulative adversity and traumahealth disparitiesloss and griefpsychotic-spectrum symptomssubstance and alcohol use

Identifiers

PMID29282872
PMCPMC5788710
OpenAlexW2778735998

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.