Evidence map›Paper›PMID 29282752›Full record

ArticleMagnetic resonance in medicine2018

Self-gated golden angle spiral cine MRI for coronary endothelial function assessment.

Gabriele Bonanno, Allison G Hays, Robert G Weiss, Michael Schär

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Free-running 3D whole-heart TMagnetic resonance in medicine · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. PET/MRI of atherosclerosis.Cardiovascular diagnosis and therapy · 2020
    Review
  8. Free-running 3D whole heart myocardial TMagnetic resonance in medicine · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gabriele BonannoDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Allison G HaysDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Robert G WeissDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Michael SchärDivision of MR Research, Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

CONTRIBUTION OF ENERGY DEPLETION TO HUMAN HEART FAILURER01HL061912 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 1999 to 2020
$8.0M
Inflammation and Coronary Endothelial FunctionR01HL120905 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2015 to 2018
$2.4M
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIVR01HL125059 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2015 to 2017
$2.4M
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIVR56HL125059 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2014 to 2014
$626k
NHLBI NIH HHS R01 HL061912NHLBI NIH HHS R01 HL120905NHLBI NIH HHS R01 HL125059NHLBI NIH HHS R56 HL125059
6 · The paper itself

Abstract

purposeDepressed coronary endothelial function (CEF) is a marker for atherosclerotic disease, an independent predictor of cardiovascular events, and can be quantified non-invasively with ECG-triggered spiral cine MRI combined with isometric handgrip exercise (IHE). However, MRI-CEF measures can be hindered by faulty ECG-triggering, leading to prolonged breath-holds and degraded image quality. Here, a self-gated golden angle spiral method (SG-GA) is proposed to eliminate the need for ECG during cine MRI.

methodsSG-GA was tested against retrospectively ECG-gated golden angle spiral MRI (ECG-GA) and gold-standard ECG-triggered spiral cine MRI (ECG-STD) in 10 healthy volunteers. CEF data were obtained from cross-sectional images of the proximal right and left coronary arteries in a 3T scanner. Self-gating heart rates were compared to those from simultaneous ECG-gating. Coronary vessel sharpness and cross-sectional area (CSA) change with IHE were compared among the 3 methods.

resultsSelf-gating precision, accuracy, and correlation-coefficient were 7.7 ± 0.5 ms, 9.1 ± 0.7 ms, and 0.93 ± 0.01, respectively (mean ± standard error). Vessel sharpness by SG-GA was equal or higher than ECG-STD (rest: 63.0 ± 1.7% vs. 61.3 ± 1.3%; exercise: 62.6 ± 1.3% vs. 56.7 ± 1.6%, P < 0.05). CSA changes were in agreement among the 3 methods (ECG-STD = 8.7 ± 4.0%, ECG-GA = 9.6 ± 3.1%, SG-GA = 9.1 ± 3.5%, P = not significant).

conclusionCEF measures can be obtained with the proposed self-gated high-quality cine MRI method even when ECG is faulty or not available. Magn Reson Med 80:560-570, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Indexed as

AdolescentAdultCoronary VesselsElectrocardiographyEndothelium, VascularFemaleHeart RateHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMaleRetrospective StudiesSignal Processing, Computer-AssistedYoung Adultatherosclerosiscine MRIcoronary endothelial functiongolden angleself-gatingspiral

Identifiers

PMID29282752
PMCPMC5910207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.