Evidence map›Paper›PMID 29282627›Full record

ArticleTranslational stroke research2018

Association Between Splenic Contraction and the Systemic Inflammatory Response After Acute Ischemic Stroke Varies with Age and Race.

Alicia Zha, Farhaan Vahidy, Jaskaren Randhawa, Kaushik Parsha, Thanh Bui, Jaroslaw Aronowski, Sean I Savitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alicia ZhaDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Farhaan VahidyDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Jaskaren RandhawaDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Kaushik ParshaDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Thanh BuiDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Jaroslaw AronowskiDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA.
Sean I SavitzDepartment of Neurology and The Institute for Stroke and Cerebrovascular Disease, McGovern Medical School, UTHealth, Houston, TX, 77030, USA. sean.i.savitz@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

THE UNIVERSITY OF TEXAS HOUSTON STROKE TRAINING PROGRAMT32NS007412 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVITZ, SEAN I · 1998 to 2023
$4.6M
NIH HHS 5 T32 NS007412NINDS NIH HHS T32 NS007412
6 · The paper itself

Abstract

Animal models have demonstrated the deleterious contribution of splenic immunocytes on secondary brain injury after stroke. While previous work has demonstrated splenic contraction (SC) in patients with acute ischemic stroke (AIS) and intracranial hemorrhage (ICH), no clinical studies have examined the relationship between the systemic inflammatory response syndrome (SIRS) with SC in stroke patients. This is a retrospective analysis of a previous prospective observational study where daily spleen sizes were evaluated in 178 acute stroke patients. Spleen contraction was based on previously established normograms of healthy volunteers from the same study. SC from the first 24 h of stroke onset was evaluated against criteria for SIRS for the first 5 days of admission after AIS. Ninety-one patients had verified AIS without concurrent infection at admission. SIRS was not associated with SC at admission. African-American patients with early SIRS had higher odds of having SC. Older patients with persistent SIRS at 72 h had lower odds of SC. At 48 h, there was significantly higher lymphocytosis and lower neutrophils present in patients with SC. Patients with SIRS at 72 h were more likely to have worse discharge mRS. This study provides evidence for an association among SC and SIRS in African-American patients suggesting that spleen changes could be a biomarker for detecting SIRS in this population. Our data also indicate a counter association between SC and a lack of SIRS in patients older than 75. Further studies are needed to ascertain how age affects this association.

Indexed as

AgedAged, 80 and overBlack or African AmericanBrain IschemiaFemaleHumansLeukocytesLymphocytesMaleNeutrophilsSpleenStrokeSystemic Inflammatory Response SyndromeTime FactorsInflammationIschemic strokeSpleenSystemic inflammatory response syndrome

Identifiers

PMID29282627
PMCPMC7233472
OpenAlexW2778313476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.