Evidence map›Paper›PMID 29282541›Full record

ArticleMedical molecular morphology2018

Creatine phosphate disodium salt protects against Dox-induced cardiotoxicity by increasing calumenin.

Yu Wang, Ying Sun, Xin Guo, Yao Fu, Jie Long, Cheng-Xi Wei, Ming Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Medical molecular morphology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yu WangInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Ying SunRadiation Center, Beijing Shijitan Hospital of Capital Medical University, Beijing, People's Republic of China.
Xin GuoInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Yao FuInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Jie LongInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China.
Cheng-Xi WeiInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China. weichengxi1224@163.com.
Ming ZhaoInner Mongolia University for the Nationalities, No. 22 Holin He Street, Tongliao, 028002, Inner Mongolia, People's Republic of China. langzhe73@163.com.
Inner Mongolia University for Nationalities · CNCapital Medical University · CN

Funding

Dr. Science research Startup funds of Inner Mongolia University for Nationalities BS345National Natural Science Foundation of China 81360587the natural science foundation of Inner Mongolia 2016BS0806
6 · The paper itself

Abstract

Inhibiting endoplasmic reticulum stress (ERS)-induced apoptosis may be a new therapeutic target in cardiovascular diseases. Creatine phosphate disodium salt (CP) has been reported to have cardiovascular protective effect, but its effects on ERS are unknown. The aim of this study was to identify the mechanism by which CP exerts its cardioprotection in doxorubicin (Dox)-induced cardiomyocytes injury. In our study, neonatal rats cardiomyocytes (NRC) was randomly divided into control group, model group, and treatment group. The cell viability and apoptosis were detected. grp78, grp94, and calumenin of the each group were monitored. To investigate the role of calumenin, Dox-induced ERS was compared in control and down-regulated calumenin cardiomyocytes. Our results showed that CP decreased Dox-induced apoptosis and relieved ERS. We found calumenin increased in Dox-induced apoptosis with CP. ERS effector C/EBP homologous protein was down-regulated by CP and it was influenced by calumenin. CP could protect NRC by inhibiting ERS, this mechanisms may be associated with its increasing of calumenin.

Indexed as

AnimalsAnimals, NewbornApoptosisCalcium-Binding ProteinsCardiotonic AgentsCardiotoxicityCells, CulturedDoxorubicinEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHeat-Shock ProteinsMyocytes, CardiacPhosphocreatineRatsTranscription Factor CHOPCalcium-Binding ProteinsCalu protein, ratCardiotonic AgentsDdit3 protein, ratDoxorubicinEndoplasmic Reticulum Chaperone BiPGRP78 protein, ratHeat-Shock ProteinsPhosphocreatineTranscription Factor CHOPCreatine phosphate disodium saltDoxorubicinEndoplasmic reticulum stress

Identifiers

PMID29282541
OpenAlexW2781068479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.