Evidence map›Paper›PMID 29282534›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study.

Lisa M Wu, Ali Amidi, Molly L Tanenbaum, Gary Winkel, Wayne A Gordon, Simon J Hall, Katrin Bovbjerg, Michael A Diefenbach

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07729969 (Early Cognitive Interventions in Digital Format for Cancer Survivors - INCOTEM), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07729969 narecruitingnot on this mapstarted 2026, after this paper: background citation

Early Cognitive Interventions in Digital Format for Cancer Survivors - INCOTEM

TypeinterventionalSponsorBiogipuzkoa Health Research InstituteRan2026 to 2028Enrolled110ConditionsCognitive Impairment, Cognitive Change, CancerArmsComputerized cognitive treatment, Virtual reality cognitive training
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effect of androgen deprivation therapy on cognitive functioning in men with prostate cancer: A systematic review.International journal of urology : official journal of the Japanese Urological Association · 2021
    Pooled it
  5. Cognitive rehabilitation for cancer-related cognitive dysfunction: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  6. Trial
  7. Trial
  8. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  9. Review
  10. Article
  11. Remote group intervention for adults with cancer-related cognitive impairment: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Cognitive Retraining and Functional Treatment (CRAFT) for adults with cancer related cognitive impairment: a preliminary efficacy study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisa M WuDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 North St. Clair, 19th floor, Chicago, IL, 60611, USA. lisa.wu1@northwestern.edu.
Ali AmidiUnit for Psychooncology and Health Psychology, Department of Oncology and Department of Psychology and Behavioural Sciences, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
Molly L TanenbaumDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Gary WinkelDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wayne A GordonDepartment of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Simon J HallDepartment of Medicine and Urology, Northwell Health, Great Neck, NY, USA.
Katrin BovbjergDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 North St. Clair, 19th floor, Chicago, IL, 60611, USA.
Michael A DiefenbachDepartment of Medicine and Urology, Northwell Health, Great Neck, NY, USA.

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Treating cognitive impairments in cancer patients via systematic light exposureK07CA184145 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WU, LISA MARIA · 2015 to 2019
$835k
American Cancer Society PF-12-041-01-CPPBNational Cancer Institute 5K07CA184145-03NCI NIH HHS K07 CA184145NCI NIH HHS P30 CA196521
6 · The paper itself

Abstract

purposeProstate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment.

methodsSixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed.

resultsFeasibility:A priori feasibility thresholds were partially met (i.e., randomization rate > 50%, retention rate > 70% excluding CCT drop-outs, but < 70% for intent-to-treat). Acceptability: Participants were mostly satisfied with CCT and found it somewhat enjoyable, though barriers to uptake existed. Preliminary efficacy: Linear mixed models indicated significant time by group effects favorable to CCT in reaction time (p = .01), but unfavorable to CCT in verbal and visual memory (ps < .05). Memory was temporarily suppressed in the CCT group at T2, but normalized by T3. There was no effect of CCT on self-reported cognitive functioning, neurobehavioral functioning, nor quality of life.

conclusionsThis study provides tentative support for the feasibility and acceptability of CCT to treat mild cognitive impairment in ADT patients. CCT had a beneficial effect on reaction time, but temporarily suppressed memory. CCT's benefits may be limited to a narrow area of functioning. Larger-scale studies are needed.

Indexed as

Psychological TechniquesAgedAndrogen AntagonistsAntineoplastic Agents, HormonalCognitionCognition DisordersCognitive DysfunctionComputer-Assisted InstructionFeasibility StudiesHumansMaleMemoryMiddle AgedPilot ProjectsProstatic NeoplasmsQuality of LifeAndrogen AntagonistsAntineoplastic Agents, HormonalAntiandrogensCancer-related cognitive impairmentCognitionComputersHormone therapyOncology

Identifiers

PMID29282534
PMCPMC5924582

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.