ReviewEuropean journal of applied physiology2018
Determinants, analysis and interpretation of the muscle compound action potential (M wave) in humans: implications for the study of muscle fatigue.
Review in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis.Experimental brain research · 2023Pooled it
- The effect of 6-day fasting on physical performance and neuromuscular control in healthy men.Scientific reports · 2026Trial
- Nerve conduction during acute blood-flow restriction with and without low-intensity exercise Nerve conduction and blood-flow restriction.Scientific reports · 2020Trial
- Recording Cortical Somatosensory Responses During Cross-Country Skiing: A Feasibility and Reproducibility EEG Study.The European journal of neuroscience · 2026Article
- Blood flow restriction induces similar peripheral stress but greater central drive impairments than systemic hypoxia during repeated cycling sprints.European journal of applied physiology · 2026Article
- Greater endogenous pain facilitation is associated with lower spinal excitability and maximal knee extension strength deficits in athletes with patellar tendinopathy.European journal of applied physiology · 2026Article
- Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Intracortical inhibition, corticospinal excitability and voluntary activation in people with and without patellofemoral pain.Experimental physiology · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results.GeroScience · 2025Article
- Spinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.Scientific reports · 2024Article
- Immediate but not prolonged effects of submaximal eccentric vs concentric fatiguing protocols on the etiology of hamstrings' motor performance fatigue.European journal of applied physiology · 2024Article
- Corticospinal and spinal responses following a single session of lower limb motor skill and resistance training.European journal of applied physiology · 2024Article
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Altitude-induced effects on neuromuscular, metabolic and perceptual responses before, during and after a high-intensity resistance training session.European journal of applied physiology · 2023Article
- Corticospinal excitability and reflex modulation in a contralateral non-stretched muscle following unilateral stretching.European journal of applied physiology · 2023Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Immediate Reduction in Spasticity of Ankle Plantar Flexors in a Stroke Patient after Treatment with a Spinning Permanent Magnet Device.Progress in rehabilitation medicine · 2023Article
- Muscle innervation zone estimation from monopolar high-density M-waves using principal component analysis and radon transform.Frontiers in physiology · 2023Article
- Increased short interval intracortical inhibition in participants with previous hamstring strain injury.European journal of applied physiology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The compound muscle action potential (M wave) has been commonly used to assess the peripheral properties of the neuromuscular system. More specifically, changes in the M-wave features are used to examine alterations in neuromuscular propagation that can occur during fatiguing contractions. The utility of the M wave is based on the assumption that impaired neuromuscular propagation results in a decrease in M-wave size. However, there remains controversy on whether the size of the M wave is increased or decreased during and/or after high-intensity exercise. The controversy partly arises from the fact that previous authors have considered the M wave as a whole, i.e., without analyzing separately its first and second phases. However, in a series of studies we have demonstrated that the first and second phases of the M wave behave in a different manner during and after fatiguing contractions. The present review is aimed at five main objectives: (1) to describe the mechanistic factors that determine the M-wave shape; (2) to analyze the various factors influencing M-wave properties; (3) to emphasize the need to analyze separately the first and second M-wave phases to adequately identify and interpret changes in muscle fiber membrane properties; (4) to advance the hypothesis that it is an increase (and not a decrease) of the M-wave first phase which reflects impaired sarcolemmal membrane excitability; and (5) to revisit the involvement of impaired sarcolemmal membrane excitability in the reduction of the force generating capacity.
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Registered trials
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