Evidence map›Paper›PMID 29282529›Full record

ReviewEuropean journal of applied physiology2018

The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis.

Felipe Damas, Cleiton A Libardi, Carlos Ugrinowitsch

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 16 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 16 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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  11. Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review.International journal of environmental research and public health · 2023
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  16. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Felipe DamasSchool of Physical Education and Sport, University of São Paulo, Av. Prof. Mello Moraes, 65, São Paulo, SP, 05508-030, Brazil. felipedamas@usp.br.ORCID http://orcid.org/0000-0001-9049-3598
Cleiton A LibardiLaboratory of Neuromuscular Adaptations to Resistance Training-MUSCULAB, Department of Physical Education, Federal University of São Carlos, Rod. Washington Luiz, km 235-SP310, São Carlos, SP, 13565-905, Brazil.
Carlos UgrinowitschSchool of Physical Education and Sport, University of São Paulo, Av. Prof. Mello Moraes, 65, São Paulo, SP, 05508-030, Brazil.
Universidade Federal de São Carlos · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303085/2015-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/24499-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/21218-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/19594-0
6 · The paper itself

Abstract

Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process. Despite substantial advances, we are far from understanding exactly how muscle hypertrophy develops during RT. The aim of the present review is to discuss new insights related to the role of skeletal muscle damage and muscle protein synthesis (MPS) in mediating RT-induced hypertrophy. Specifically, the thesis that in the early phase of RT (≤ 4 previous RT sessions) increases in muscle cross-sectional area are mostly attributable to muscle damage-induced muscle swelling; then (after ~ 10 sessions), a modest magnitude of muscle hypertrophy ensues; but only during a latter phase of RT (after ~ 18 sessions) is true muscle hypertrophy observed. We argue that the initial increases in MPS post-RT are likely directed to muscle repair and remodelling due to damage, and do not correlate with eventual muscle hypertrophy induced by several RT weeks. Increases in MPS post-RT session only contribute to muscle hypertrophy after a progressive attenuation of muscle damage, and even more significantly when damage is minimal. Furthermore, RT protocols that do not promote significant muscle damage still induce similar muscle hypertrophy and strength gains compared to conditions that do promote initial muscle damage. Thus, we conclude that muscle damage is not the process that mediates or potentiates RT-induced muscle hypertrophy.

Indexed as

HumansHypertrophyMuscle ProteinsMuscle, SkeletalMyalgiaPhysical Conditioning, HumanMuscle ProteinsEdemaMyofibrillar protein synthesisResistance exerciseSatellite cellsSkeletal muscleSoreness

Identifiers

PMID29282529
OpenAlexW2776736223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.