Evidence map›Paper›PMID 29282364›Full record

ArticleThe pharmacogenomics journal2018

Mir-pharmacogenetics of Vincristine and peripheral neurotoxicity in childhood B-cell acute lymphoblastic leukemia.

Ángela Gutierrez-Camino, Maitane Umerez, Idoia Martin-Guerrero, Nagore García de Andoin, Borja Santos, Ana Sastre, Aizpea Echebarria-Barona, Itziar Astigarraga, Aurora Navajas, Africa Garcia-Orad

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  16. MiRNA Dysregulation in Childhood Hematological Cancer.International journal of molecular sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ángela Gutierrez-CaminoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.
Maitane UmerezDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.
Idoia Martin-GuerreroDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.
Nagore García de AndoinDepartment of Pediatrics, University Hospital Donostia, San Sebastian, Spain.
Borja SantosDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.
Ana SastreDepartment of Oncohematology, University Hospital La Paz, Madrid, Spain.
Aizpea Echebarria-BaronaDepartment of Pediatrics, University Hospital Cruces, Barakaldo, Spain.
Itziar AstigarragaDepartment of Pediatrics, University Hospital Cruces, Barakaldo, Spain.
Aurora NavajasDepartment of Pediatrics, University of the Basque Country, UPV/EHU, Leioa, Spain.
Africa Garcia-OradDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain. africa.garciaorad@ehu.eus.ORCID http://orcid.org/0000-0002-5575-3080
University of the Basque Country · ESBiogipuzkoa Health Research Institute · ESHospital de Cruces · ESHospital Universitario La Paz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vincristine (VCR), an important component of childhood acute lymphoblastic leukemia (ALL) therapy, can cause sensory and motor neurotoxicity. This neurotoxicity could lead to dose reduction or treatment discontinuation, which could in turn reduce survival. In this line, several studies associated peripheral neurotoxicity and polymorphisms in genes involved in pharmacokinetics (PK) and pharmacodynamics (PD) of VCR. Nowadays, it is well known that these genes are regulated by microRNAs (miRNAs) and SNPs in miRNAs could modify their levels or function. Therefore, the aim of this study was to determine whether SNPs in miRNAs could be associated with VCR-induced neurotoxicity. To achieve this aim, we analyzed all the SNPs in miRNAs (minor allele frequency (MAF) ≥ 0.01) which could regulate VCR-related genes in a large cohort of Spanish children with B-cell precursor ALL (B-ALL) homogeneously treated with LAL/SHOP protocols. We identified the A allele of rs12402181 in the seed region of miR-3117-3p, that could affect the binding with ABCC1 and RALBP1 gene, and C allele of rs7896283 in pre-mature sequence of miR-4481, which could be involved in peripheral nerve regeneration, significantly associated with VCR-induced neurotoxicity. These findings point out the possible involvement of two SNPs in miRNA associated with VCR-related neurotoxicity.

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideAge of OnsetAntineoplastic Agents, PhytogenicATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersChildChild, PreschoolFemaleGene FrequencyGenetic Predisposition to DiseaseGTPase-Activating ProteinsHumansInfantMaleMicroRNAsAntineoplastic Agents, PhytogenicATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersGTPase-Activating ProteinsMicroRNAsmultidrug resistance-associated protein 1RALBP1 protein, humanVincristine

Identifiers

PMID29282364
OpenAlexW2779217651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.