ArticleProceedings of the National Academy of Sciences of the United States of America2018
Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste bud cell subtypes via KIT inhibition.Development (Cambridge, England) · 2026Article
- Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Conserved differential expression of DDX helicase and CPEB genes in skeletal muscles potentially influences neuromuscular junctions during aging: a computational analysis.Biogerontology · 2026Article
- Gas1 regulates embryonic tongue muscle proliferation, differentiation and maturation via alternative pathways to Hedgehog signaling.Development (Cambridge, England) · 2025Article
- Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration.Biomedicines · 2025Article
- BDNF-VGF Pathway Aggravates Incision Induced Acute Postoperative Pain via Upregulating the Neuroinflammation in Dorsal Root Ganglia.Molecular neurobiology · 2025Article
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Trigeminal innervation and tactile responses in mouse tongue.Cell reports · 2024Article
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023Article
- Anterior and Posterior Tongue Regions and Taste Papillae: Distinct Roles and Regulatory Mechanisms with an Emphasis on Hedgehog Signaling and Antagonism.International journal of molecular sciences · 2023Review
- High-sucrose diet exposure is associated with selective and reversible alterations in the rat peripheral taste system.Current biology : CB · 2022Article
- Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition.Cell and tissue research · 2022Article
- Somatosensory innervation of healthy human oral tissues.The Journal of comparative neurology · 2021Article
- The Fungiform Papilla Is a Complex, Multimodal, Oral Sensory Organ.Current opinion in physiology · 2021Article
- Growth Factors as Axon Guidance Molecules: Lessons FromFrontiers in neuroscience · 2021Review
- Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons.Scientific reports · 2020Article
- Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway.Cell cycle (Georgetown, Tex.) · 2020Article
- Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.Cell and tissue research · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The development of the taste system relies on the coordinated regulation of cues that direct the simultaneous development of both peripheral taste organs and innervating sensory ganglia, but the underlying mechanisms remain poorly understood. In this study, we describe a novel, biphasic function for glial cell line-derived neurotrophic factor (GDNF) in the development and subsequent diversification of chemosensory neurons within the geniculate ganglion (GG). GDNF, acting through the receptor tyrosine kinase Ret, regulates the expression of the chemosensory fate determinant Phox2b early in GG development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.