ArticleProceedings of the National Academy of Sciences of the United States of America2018
Expression of an active Gα
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 71 citations in OpenAlex.
- RANKL inhibition reduces lesional cellularity and GαBone research · 2024Trial
- Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Individualized antiresorptive therapy in fibrous dysplasia and McCune-Albright syndrome: A retrospective cohort study.Bone reports · 2026Article
- Intensive, interdisciplinary pain treatment in fibrous dysplasia/McCune-Albright syndrome.JBMR plus · 2026Article
- Protocol for the isolation of inducible GαsSTAR protocols · 2026Article
- Single-cell landscape of lymphoid and myeloid heterogeneity across type-stratified craniofacial lesions in polyostotic fibrous dysplasia.Frontiers in immunology · 2026Article
- Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration.Science signaling · 2025Article
- Article
- Elevated surface La promotes hyperfusion and contributes to impaired resorption in osteopetrosis.bioRxiv : the preprint server for biology · 2025Article
- Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells.American journal of human genetics · 2025Article
- Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research.Orphanet journal of rare diseases · 2025Review
- Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia.Nature communications · 2025Article
- Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Treatment approach with clinical follow-up in monostotic fibrous dysplasia: a case series.Journal of medical case reports · 2025Article
- Arthroscopic-assisted uni-portal non-coaxial endoscopic surgery treatment of fibrous dysplasia of the femur: a minimally invasive alternative to open surgery.BMC musculoskeletal disorders · 2025Article
- Skeletal stem and progenitor cells in bone physiology, ageing and disease.Nature reviews. Endocrinology · 2025Review
- Postmenopausal osteoporosis increases periodontal inflammation and the pathogenicity of the oral microbiota in a rat model.Journal of oral microbiology · 2025Article
- Update on the medical management of fibrous dysplasia of the bone.Therapeutic advances in endocrinology and metabolism · 2025Review
- Pediatric Fibrous Dysplasia of the Skull Base: Update on Management and Treatment.Brain sciences · 2024Review
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.JBMR plus · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Xuefeng ZhaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Peng DengState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Ramiro Iglesias-BartolomeNational Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Panomwat AmornphimolthamMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093.
Dana J SteffenMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093.
Yunyun JinDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115.
Alfredo A MolinoloMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093.
Luis Fernandez de CastroSection on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.
Diana OvejeroSection on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.
Quan YuanState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID 0000-0002-2836-1081
Qianming ChenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xianglong HanState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Ding BaiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Susan S TaylorDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
Yingzi YangDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115.ORCID 0000-0003-3933-887X
Michael T CollinsSection on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.
J Silvio GutkindMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093; sgutkind@ucsd.edu.
Sichuan University · CNUniversity of California San Diego · USNational Institutes of Health · USHarvard University · US
Funding
Skeletal Disorders and Mineral Homeostasis SectionZIADE000649 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI COLLINS, MICHAEL · 2009 to 2025
$32.8MGRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5MSignaling pathways regulating stem cell fate decisionsZIABC011763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI IGLESIAS-BARTOLOME, RAMIRO · 2017 to 2025
$7.5MGas-Hedgehog signaling in intramembranous bone formation and expansionR01DE025866 · NIDCR · HARVARD MEDICAL SCHOOL · PI Yingzi Yang · 2016 to 2026
$5.3MROLE OF G PROTEINS IN GROWTH CONTROL AND CARCINOGENESISZ01DE000551 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI GUTKIND, J · 1992 to 2008
$3.4MIntramural NIH HHS Z01 DE000551NIDCR NIH HHS R01 DE025866NIGMS NIH HHS T32 GM007752
Abstract
Fibrous dysplasia (FD) is a disease caused by postzygotic activating mutations of
Indexed as
AnimalsAnti-Bacterial AgentsBone and BonesBone DevelopmentCell DifferentiationDoxycyclineFibrous Dysplasia of BoneGene Expression RegulationGene Expression Regulation, DevelopmentalGTP-Binding Protein alpha Subunits, GsMesenchymal Stem CellsMiceMutationAnti-Bacterial AgentsDoxycyclineGTP-Binding Protein alpha Subunits, Gsfibrous dysplasiaGNASmouse modelsPKAskeletal stem cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.