Evidence map›Paper›PMID 29282302›Full record

ArticleJournal of lipid research2018

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis.

Sergei A Novgorodov, Joshua R Voltin, Monika A Gooz, Li Li, John J Lemasters, Tatyana I Gudz

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  5. Traumatic brain injury-related ferroptosis: current perspectives.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  6. Ferroptosis: a new target for depression prevention and treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  7. Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025
    Review
  8. Sphingolipid metabolism and regulated cell death in malignant melanoma.Apoptosis : an international journal on programmed cell death · 2024
    Review
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  11. Article
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  15. Article
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  18. Sirtuin-3: A potential target for treating several types of brain injury.Frontiers in cell and developmental biology · 2023
    Review
  19. The roles of sirtuins in ferroptosis.Frontiers in physiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sergei A NovgorodovDepartments of Neuroscience Medical University of South Carolina, Charleston, SC 29425.
Joshua R VoltinDepartments of Neuroscience Medical University of South Carolina, Charleston, SC 29425.
Monika A GoozDepartments of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425.
Li LiDepartments of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425.
John J LemastersDepartments of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425.
Tatyana I GudzDepartments of Neuroscience Medical University of South Carolina, Charleston, SC 29425 gudz@musc.edu.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

RESEARCH PILOT PROJECTS PROGRAMP30GM103339 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANNUN, YUSUF AWNI · 2012 to 2016
$5.4M
Mechanisms of I/R Injury to HepatocytesR01DK073336 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2007 to 2017
$2.5M
Role and Regulation of SIRT3 in White MatterR01NS083544 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GUDZ, TATYANA I. · 2014 to 2018
$1.6M
Confocal/Multiphoton Microscope UpgradeS10OD018113 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2015 to 2015
$570k
Targeting Sphingosine to Treat Brain InjuryI01BX002991 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI GUDZ, TATYANA I. · 2016 to 2019
–
BLRD VA I01 BX002991NIDDK NIH HHS R01 DK073336NIGMS NIH HHS P30 GM103339NIH HHS S10 OD018113NINDS NIH HHS R01 NS083544
6 · The paper itself

Abstract

Inhibiting the glutamate/cystine antiporter system x

Indexed as

AnimalsCells, CulturedFemaleGlutamic AcidMiceMitochondriaNecrosisOligodendrogliaPregnancyRatsRats, Sprague-DawleySphingomyelin PhosphodiesteraseGlutamic AcidSphingomyelin Phosphodiesterasebrain lipidsferroptosisglutamate/cystine antiporterlipids/peroxidationmitochondriaoligodendrocytessirtuinsphingolipids

Identifiers

PMID29282302
PMCPMC5794425
OpenAlexW2776838701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.