Evidence map›Paper›PMID 29282285›Full record

ArticleMolecular biology of the cell2018

Cross-linkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis.

Carlos Patino Descovich, Daniel B Cortes, Sean Ryan, Jazmine Nash, Li Zhang, Paul S Maddox, Francois Nedelec, Amy Shaub Maddox

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Non-Muscle Myosin II A: Friend or Foe in Cancer?International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Physical mechanisms of ESCRT-III-driven cell division.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Roles of Actin in the Morphogenesis of the EarlyInternational journal of molecular sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlos Patino DescovichDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377.
Daniel B CortesDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377.
Sean RyanDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377.
Jazmine NashDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377.
Li ZhangInstitute for Research in Immunology and Cancer, University of Montréal, Montréal, QC H3C 3T5, Canada.
Paul S MaddoxDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377.
Francois NedelecCell Biology and Biophysics Unit, EMBL, 69117 Heidelberg, Germany.
Amy Shaub MaddoxDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 32377 asm@unc.edu.

Funding

Super-resolution of the Mechanisms of Cell Shape Change in Cytokinesis - the Zeiss LSM800/AiryscanR01GM102390 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MADDOX, AMY SHAUB · 2012 to 2020
$2.9M
NIGMS NIH HHS R01 GM102390
6 · The paper itself

Abstract

Cell shape changes such as cytokinesis are driven by the actomyosin contractile cytoskeleton. The molecular rearrangements that bring about contractility in nonmuscle cells are currently debated. Specifically, both filament sliding by myosin motors, as well as cytoskeletal cross-linking by myosins and nonmotor cross-linkers, are thought to promote contractility. Here we examined how the abundance of motor and nonmotor cross-linkers affects the speed of cytokinetic furrowing. We built a minimal model to simulate contractile dynamics in the

Indexed as

CytokinesisActinsActomyosinAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoskeletonMicrotubulesMyosin Type IIActinsActomyosinCaenorhabditis elegans ProteinsMyosin Type II

Identifiers

PMID29282285
PMCPMC6004588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.