ArticleBMJ open2017
Developing and validating a novel multisource comorbidity score from administrative data: a large population-based cohort study from Italy.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04352556 (SARS-CoV-2 Infection in Patients With Hematological Malignancies), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SARS-CoV-2 Infection in Patients With Hematological Malignancies: the Italian Hematology Alliance
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How to assess multimorbidity: a systematic review.Frontiers in public health · 2025Pooled it
- Measuring multimorbidity beyond counting diseases: systematic review of community and population studies and guide to index choice.BMJ (Clinical research ed.) · 2020Pooled it
- Adherence to antidiabetic drug therapy and reduction of fatal events in elderly frail patients.Cardiovascular diabetology · 2023Trial
- Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case-Control Study Among Community-Dwelling Older Adults.Drugs & aging · 2026Article
- Prevalence and incidence of heart failure hospitalizations from 2005 to 2023 and determinants of optimal treatment implementation in clinical practice: A population-based study in Northern Italy.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Evaluating cross-country applicability of morbidity scores: validation of the Multisource Comorbidity Score in Catalonia.European journal of public health · 2026Observational
- Comparison of antibiotic prescription indexes by patient and physician gender and age: a cross-sectional study based on administrative data.BMC primary care · 2026Article
- State sequence analysis for a deeper understanding of treatment adherence patterns in fragility fracture patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Observational
- Penalized likelihood optimization for adaptive neighborhood clustering in time-to-event data with group-level heterogeneity.Biostatistics (Oxford, England) · 2026Article
- Antihypertensive treatment in young adults and cardiovascular risk: a population-based cohort study.European heart journal · 2026Article
- Percutaneous coronary intervention in nonagenarians with acute myocardial infarction: a 15-year population-based study.Scientific reports · 2026Article
- Adherence to perindopril/amlodipine/atorvastatin combination according to the administration strategy.European heart journal. Quality of care & clinical outcomes · 2025Article
- Frequent Users of Emergency Departments: Analysis of the Characteristics and Geographical Distribution in a Local Health Authority in Rome, Italy.Healthcare (Basel, Switzerland) · 2025Article
- Association between previous SARs-CoV-2 infection and new prescription of antidepressant drugs: a case-control study in Friuli Venezia Giulia region, Italy.European archives of psychiatry and clinical neuroscience · 2025Article
- Atrial Fibrillation Is Associated With Increased In-Hospital and 1-Year Mortality in Patients Receiving Hemodialysis With ST Elevation Myocardial Infarction: A Retrospective Cohort Study.Kidney medicine · 2025Article
- Medication Use Before and After Different Bariatric Surgery Procedures: Results from a Population-Based Cohort Study.Obesity surgery · 2025Observational
- Twenty-year trend in comorbidity score among adults aged 50-85 years in Lombardy, Italy: Age-Cohort-Period analysis and future trends.BMJ open · 2025Observational
- Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection.Scientific reports · 2025Article
- Predictors and benefits of lipid-lowering therapy initiation after an atherosclerotic cardiovascular event: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- Association between organizational characteristics of community-oriented mental health facilities and treatment adequacy. A multilevel analysis from Lombardy, Italy.Frontiers in health services · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo develop and validate a novel comorbidity score (multisource comorbidity score (MCS)) predictive of mortality, hospital admissions and healthcare costs using multiple source information from the administrative Italian National Health System (NHS) databases.
methodsAn index of 34 variables (measured from inpatient diagnoses and outpatient drug prescriptions within 2 years before baseline) independently predicting 1-year mortality in a sample of 500 000 individuals aged 50 years or older randomly selected from the NHS beneficiaries of the Italian region of Lombardy (training set) was developed. The corresponding weights were assigned from the regression coefficients of a Weibull survival model. MCS performance was evaluated by using an internal (ie, another sample of 500 000 NHS beneficiaries from Lombardy) and three external (each consisting of 500 000 NHS beneficiaries from Emilia-Romagna, Lazio and Sicily) validation sets. Discriminant power and net reclassification improvement were used to compare MCS performance with that of other comorbidity scores. MCS ability to predict secondary health outcomes (ie, hospital admissions and costs) was also investigated.
resultsPrimary and secondary outcomes progressively increased with increasing MCS value. MCS improved the net 1-year mortality reclassification from 27% (with respect to the Chronic Disease Score) to 69% (with respect to the Elixhauser Index). MCS discrimination performance was similar in the four regions of Italy we tested, the area under the receiver operating characteristic curves (95% CI) being 0.78 (0.77 to 0.79) in Lombardy, 0.78 (0.77 to 0.79) in Emilia-Romagna, 0.77 (0.76 to 0.78) in Lazio and 0.78 (0.77 to 0.79) in Sicily.
conclusionMCS seems better than conventional scores for predicting health outcomes, at least in the general population from Italy. This may offer an improved tool for risk adjustment, policy planning and identifying patients in need of a focused treatment approach in the everyday medical practice.
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