Evidence map›Paper›PMID 29282259›Full record

Trial reportBMJ open2017

Exercise response in Parkinson's disease: insights from a cross-sectional comparison with sedentary controls and a per-protocol analysis of a randomised controlled trial.

Foteini Mavrommati, Johnny Collett, Marloes Franssen, Andy Meaney, Claire Sexton, Andrea Dennis-West, Jill F Betts, Hooshang Izadi, Marko Bogdanovic, Martin Tims and 2 more

Open access · goldAbstract readClinical Trial, Phase IIPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
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  8. Review
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  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Foteini MavrommatiOxford University Hospitals Research and Development Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0001-6520-2111
Johnny CollettOxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK.
Marloes FranssenPrimary Care Clinical Trials Unit, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Andy MeaneyOxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK.
Claire SextonFMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Andrea Dennis-WestNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jill F BettsFMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Hooshang IzadiDepartment of Mechanical Engineering and Mathematical Sciences, Oxford Brookes University, Oxford, UK.
Marko BogdanovicDepartment of Neurology, Royal Berkshire Hospital, Reading, UK.
Martin TimsOxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK.
Andrew FarmerPrimary Care Clinical Trials Unit, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Helen DawesOxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK.
Oxford Brookes University · GBUniversity of Oxford · GBRoyal Berkshire Hospital · GB

Funding

Department of Health PB-PG-0110-20250
6 · The paper itself

Abstract

objectivesTo investigate the acute and adaptation cardiovascular and metabolic training responses in people with Parkinson's disease (pwP).

design(1) A cross-sectional study of exercise response of pwP compared with sedentary controls and (2) an interventional study of exercise training in pwP.

settingCommunity leisure facilities.

participantspwP (n=83) and sedentary controls (n=55).

interventionsStudy 1 included participants from a two-arm-parallel single-blind phase II randomised controlled trial (RCT), that undertook a baseline maximal incremental exercise test and study 2 included those randomised to the exercise group in the RCT, who completed a 6-month weekly exercise programme (n=37). The intervention study 2 was a prescribed exercise program consisting of sessions lasting 60 min, two times a week over a 6-month period. The control group followed the same protocol which derived the same cardiorespiratory parameters, except that they were instructed to aim for a cadence of ~60 revolutions per minute and the unloaded phase lasted 3 min with an initial step of 25 W. PRIMARY AND SECONDARY OUTCOME MEASURES: Stepwise incremental exercise test to volitional exhaustion was the primary outcome measure.

resultsStudy 1 showed higher maximum values for heart rate (HR), VO

conclusionsAn abnormal cardiovascular response to exercise was observed in pwP compared to controls. After the exercise programme, metabolic deficiencies remained for pwP. These observations add to the pathogenic understanding of PD, acknowledge an underling metabolic contribution and support that certain cardiovascular symptoms may improve as a result of this type of exercise.

Indexed as

AdultAgedAged, 80 and overCardiovascular SystemCross-Sectional StudiesExerciseExercise TestExercise TherapyFemaleHeart RateHumansMaleMiddle AgedParkinson DiseaseQuality of LifeRegression Analysiscardiovascularexercisemetabolismparkinson-s diseaserehabilitation medicine

Identifiers

PMID29282259
PMCPMC5770916
OpenAlexW2778662161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.