ArticleThe Journal of experimental medicine2018
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8
Abstract read
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Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Targeting DGAT1 reprograms lipid landscape and restores CD8⁺ T cell immunity in pancreatic cancer.Nature communications · 2026Article
- Double negative T cells decline in inflammatory reproductive dysfunction.Scientific reports · 2026Article
- Advantages and Possibility of Transcription Factors FOXOs in HCC.Cell biochemistry and function · 2025Review
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner.Science immunology · 2025Article
- Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes.Nature communications · 2025Article
- A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells.Nature immunology · 2025Article
- Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans.Cell research · 2024Article
- Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity.Communications biology · 2024Article
- Article
- TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TNature immunology · 2024Article
- Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.Nature communications · 2024Article
- Enhancing the Efficacy of CAR-T Cell Therapy: A Comprehensive Exploration of Cellular Strategies and Molecular Dynamics.Journal of cancer immunology · 2024Article
- FOXO1 is a master regulator of CAR T memory programming.Research square · 2023Article
- Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy.Journal of hematology & oncology · 2023Review
- Vaccine adjuvant-elicited CD8Cell reports · 2023Article
- Article
- Review
- Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis.PLoS pathogens · 2023Article
- Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.The Journal of experimental medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Arnaud DelpouxMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.ORCID 0000-0003-4963-9676
Rodrigo Hess MicheliniMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.ORCID 0000-0001-5509-5164
Shilpi VermaDivision of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA.
Chen-Yen LaiMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.
Kyla D OmilusikMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.
Daniel T UtzschneiderMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.
Alec J RedwoodInstitute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia.ORCID 0000-0001-8601-8292
Ananda W GoldrathMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA.
Chris A BenedictDivision of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA.ORCID 0000-0001-7816-656X
Stephen M HedrickMolecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla CA shedrick@ucsd.edu.ORCID 0000-0002-6345-8751
Funding
T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1MCELL BIOLOGY &GENETICS OF THYMOCYTE NEGATIVE SELECTIONR01AI037988 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEDRICK, STEPHEN M · 1995 to 2015
$5.0MThe role of TRAIL in immune control of cytomegalovirusR01AI101423 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI BENEDICT, CHRISTOPHER A · 2013 to 2023
$4.6MCD4 T cell control of cytomegalovirusR01AI139749 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI BENEDICT, CHRISTOPHER A · 2019 to 2023
$3.2MT cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0MA molecular basis for control of T cell memoryR01AI103440 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEDRICK, STEPHEN M · 2013 to 2017
$2.3MNecroptosis and adaptive immunity to virus infectionR21AI113349 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI BENEDICT, CHRISTOPHER A, UPTON, JASON W · 2016 to 2017
$493kThe role of TRAIL in immune control of cytomegalovirusR56AI101423 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI BENEDICT, CHRISTOPHER A · 2012 to 2012
$435kNIAID NIH HHS R01 AI037988NIAID NIH HHS R01 AI101423NIAID NIH HHS R01 AI103440NIAID NIH HHS R01 AI139749NIAID NIH HHS R21 AI113349NIAID NIH HHS R37 AI067545NIAID NIH HHS R56 AI101423
Abstract
Upon infection with an intracellular pathogen, cytotoxic CD8
Indexed as
Clonal AnergyImmunologic MemoryAdoptive TransferAnimalsAntigens, ViralCD8-Positive T-LymphocytesCell DifferentiationCell SurvivalForkhead Box Protein O1Hepatocyte Nuclear Factor 1-alphaLectins, C-TypeLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusAntigens, ViralForkhead Box Protein O1Foxo1 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseKlrg1 protein, mouseLectins, C-TypeReceptors, Immunologic
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LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.