ArticleThe Journal of experimental medicine2018
Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- The dynamics of hematopoiesis over the human lifespan.Nature methods · 2025Article
- Stem Cell Origin of Cancer: Clinical Implications beyond Immunotherapy for Drug versus Therapy Development in Cancer Care.Cancers · 2024Article
- PD-L1-expressing tumor-associated macrophages are immunostimulatory and associate with good clinical outcome in human breast cancer.Cell reports. Medicine · 2024Article
- PD-L1 blockade immunotherapy rewires cancer-induced emergency myelopoiesis.Frontiers in immunology · 2024Article
- Single-cell RNA sequencing analysis and Alzheimer's disease: a bibliometric analysis.American journal of neurodegenerative disease · 2023Article
- Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.Cell reports · 2022Article
- Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics.Cell research · 2022Article
- Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.Genes & development · 2020Article
- Model-based cell clustering and population tracking for time-series flow cytometry data.BMC bioinformatics · 2019Article
- Association Between Intra-Tumoral Immune Response and Programmed Death Ligand 1 (PD-L1) in Gastric Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.The Journal of experimental medicine · 2019Article
- Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.Stem cell reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Hematopoietic stem cells (HSCs) mature from pre-HSCs that originate in the major arteries of the embryo. To identify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo. We purified and compared the transcriptomes of pre-HSCs, HSCs matured ex vivo, and fetal liver HSCs. We found that HSC maturation in vivo or ex vivo is accompanied by the down-regulation of genes involved in embryonic development and vasculogenesis, and up-regulation of genes involved in hematopoietic organ development, lymphoid development, and immune responses. Ex vivo matured HSCs more closely resemble fetal liver HSCs than pre-HSCs, but are not their molecular equivalents. We show that ex vivo-matured and fetal liver HSCs express programmed death ligand 1 (PD-L1). PD-L1 does not mark all pre-HSCs, but cell surface PD-L1 was present on HSCs matured ex vivo. PD-L1 signaling is not required for engraftment of embryonic HSCs. Hence, up-regulation of PD-L1 is a correlate of, but not a requirement for, HSC maturation.
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Registered trials
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