ArticleRadiation oncology (London, England)2017
Small field dosimetry for the small animal radiotherapy research platform (SARRP).
Article in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The importance of standardization and challenges of dosimetry in conventional preclinical radiation biology research.The British journal of radiology · 2025Review
- Novel radiation and targeted therapy combinations for improving rectal cancer outcomes.Expert reviews in molecular medicine · 2024Review
- Dosimetric characterization of a rotating anode x-ray tube for FLASH radiotherapy research.Medical physics · 2024Article
- Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX.Cancer research · 2023Article
- Characterization of Inorganic Scintillator Detectors for Dosimetry in Image-Guided Small Animal Radiotherapy Platforms.Cancers · 2023Article
- Small animal models of localized heart irradiation.Methods in cell biology · 2022Article
- Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber.Scientific reports · 2021Article
- Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition.Journal of visualized experiments : JoVE · 2021Article
- Pre-clinical modelling of rectal cancer to develop novel radiotherapy-based treatment strategies.Oncology reviews · 2021Article
- Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives.Cells · 2020Review
- Custom-designed Small Animal focal iRradiation Jig (SARJ): design, manufacture and dosimetric evaluation.BJR open · 2020Article
- Article
- Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy.The British journal of radiology · 2019Review
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Authors and funding
12 authors.
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Abstract
backgroundPreclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image guided therapy (IGRT) research to be performed by combining high-resolution cone beam computed tomography (CBCT) imaging with an isocentric irradiation system. Such platforms are capable of replicating modern clinical systems similar to those that integrate a linear accelerator with on-board CBCT image guidance.
methodsIn this study, we present a dosimetric evaluation of the small animal radiotherapy research platform (SARRP, Xstrahl Inc.) focusing on small field dosimetry. Physical dosimetry was assessed using ion chamber for calibration and radiochromic film, investigating the impact of beam focus size on the dose rate output as well as beam characteristics (beam shape and penumbra). Two film analysis tools) have been used to assess the dose output using the 0.5 mm diameter aperture.
resultsGood agreement (between 1.7-3%) was found between the measured physical doses and the data provided by Xstrahl for all apertures used. Furthermore, all small field dosimetry data are in good agreement for both film reading methods and with our Monte Carlo simulations for both focal spot sizes. Furthermore, the small focal spot has been shown to produce a more homogenous beam with more stable penumbra over time.
conclusionsFilmQA Pro is a suitable tool for small field dosimetry, with a sufficiently small sampling area (0.1 mm) to ensure an accurate measurement. The electron beam focus should be chosen with care as this can potentially impact on beam stability and reproducibility.
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