Evidence map›Paper›PMID 29282126›Full record

ArticleParasites & vectors2017

The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa.

Anna R Last, Sarah E Burr, Emma Harding-Esch, Eunice Cassama, Meno Nabicassa, Chrissy H Roberts, David C W Mabey, Martin J Holland, Robin L Bailey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anna R LastClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. anna.last@lshtm.ac.uk.
Sarah E BurrClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Emma Harding-EschClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Eunice CassamaPrograma Nacional de Saúde de Visão, Ministério de Saúde Publica, P.O. Box 50, Avenida de Unidade Africana, Bisssau, Guinea-Bissau.
Meno NabicassaPrograma Nacional de Saúde de Visão, Ministério de Saúde Publica, P.O. Box 50, Avenida de Unidade Africana, Bisssau, Guinea-Bissau.
Chrissy H RobertsClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
David C W MabeyClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Martin J HollandClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Robin L BaileyClinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
University of London · GBLondon School of Hygiene & Tropical Medicine · GB

Funding

Wellcome TrustWellcome Trust 097330/Z/11/Z
6 · The paper itself

Abstract

backgroundTrachoma, a neglected tropical disease, is caused by ocular infection with Chlamydia trachomatis (Ct). The World Health Organization (WHO) recommends three annual rounds of community mass drug treatment with azithromycin (MDA) if the prevalence of follicular trachoma in 1-9 year olds (TF

resultsPre-MDA TF

conclusionsDespite a significant reduction in the number of clusters of Ct infection, mean Ct load, disease severity and presence of clusters of cases of high load Ct infection suggesting the beginning of trachoma control in isolated island communities, following a single round of MDA we demonstrate that transmission is still ongoing. These detailed data are useful in understanding the epidemiology of ocular Ct infection in the context of MDA and the tools employed may have utility in determining trachoma elimination and surveillance activities in similar settings.

Indexed as

Bacterial LoadMass Drug AdministrationAnti-Bacterial AgentsAzithromycinChlamydia trachomatisConjunctivaCross-Sectional StudiesGuinea-BissauPolymerase Chain ReactionSeverity of Illness IndexTrachomaTreatment OutcomeAnti-Bacterial AgentsAzithromycinBacterial loadChlamydia trachomatisCommunity mass treatmentDisease severitySpatial clusteringTrachoma

Identifiers

PMID29282126
PMCPMC5745817
OpenAlexW2775939306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.