ArticleJournal of enzyme inhibition and medicinal chemistry2018
One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells.
Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Antimicrobial, anticancer activities and molecular docking of eco-friendly chitosan nanocapsule loaded with biosynthesized titanium nanoparticles byFrontiers in microbiology · 2026Article
- Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy.RSC advances · 2025Article
- Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancer.Frontiers in immunology · 2025Article
- Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore.Current topics in medicinal chemistry · 2024Review
- Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFRRSC advances · 2023Article
- Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold.Molecules (Basel, Switzerland) · 2023Review
- Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies.Journal of hematology & oncology · 2022Review
- Choline Chloride-Based DES as Solvents/Catalysts/Chemical Donors in Pharmaceutical Synthesis.Molecules (Basel, Switzerland) · 2021Review
- Modular Synthesis and Antiproliferative Activity of New Dihydro-1Pharmaceuticals (Basel, Switzerland) · 2021Article
- Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agentsRSC advances · 2021Article
- Spirocyclic derivatives as antioxidants: a review.RSC advances · 2021Review
- Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Novel [(Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation.Marine drugs · 2020Article
- Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- 5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis.Molecular diversity · 2019Review
- Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights.International journal of molecular sciences · 2019Article
- Benzene constructionChemical science · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets. In our endeavour towards the development of novel anti-TNBC agents, herein we report a one-pot three-component synthesis of novel spirooxindoles 6a-p, and evaluation of their potential anti-proliferative activity towards TNBC MDA-MB-231 cells. Spirooxindoles 6a, 6e and 6i emerged as the most potent analogues with IC
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