ArticleCell reports2017
The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
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Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
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- Mitochondrial Gene Signature Reveals Novel Diagnostic Biomarkers for Autism Spectrum Disorder.Molecular neurobiology · 2026Article
- Alpha-Ketoglutarate: A Metabolic Regulator of Cellular Homeostasis and Pathophysiology.Biomedicines · 2026Review
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway.European journal of medical research · 2025Article
- Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism.Molecular brain · 2024Article
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- Expanding the genetic and phenotypic spectrum of Baker-Gordon syndrome: a newJournal of genetics · 2024Article
- Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice.Nature communications · 2023Article
- Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Pre-and Postfusion Tuning of Regulated Exocytosis by Cell Metabolites.Function (Oxford, England) · 2023Article
- mTOR/α-ketoglutarate signaling: impact on brain cell homeostasis under ischemic conditions.Frontiers in cellular neuroscience · 2023Review
- Gene Expression Analysis inInternational journal of molecular sciences · 2022Article
- Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III ineLife · 2022Article
- Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS.Metabolites · 2022Article
- mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection.BBA advances · 2022Article
- An Overview of Mitochondrial Protein Defects in Neuromuscular Diseases.Biomolecules · 2021Review
- Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Berrak UgurProgram in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Huan BaoDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA; Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53705, USA.
Michal StawarskiDepartment of Biological Sciences and Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA.
Lita R DuraineHoward Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Zhongyuan ZuoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Yong Qi LinThe Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
G Gregory NeelyThe Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Gregory T MacleodDepartment of Biological Sciences and Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA.
Edwin R ChapmanDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA; Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53705, USA.
Hugo J BellenProgram in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address: hbellen@bcm.edu.
Baylor College of Medicine · USFlorida Atlantic University · USUniversity of Sydney · AUHoward Hughes Medical Institute · USTexas Children's Hospital · USUniversity of Wisconsin–Madison · US
Funding
Transposon induced disruption of most Drosophila genesR01GM067858 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2003 to 2020
$15.7MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MSynaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7MExpansion and characterization of the Drosophila Toolkit to study SARS-CoV-2R24OD022005 · OD · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2016 to 2023
$7.4MThe multiple roles of mitochondria in synaptic transmissionR01NS061914 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MACLEOD, GREGORY TALISKER · 2008 to 2016
$2.6MMapping and rescuing EMS-induced lethal mutations on the Drosophila X ChromosomeRC4GM096355 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2010 to 2010
$1.7MMolecularly defined duplications for the X-chromosome and large autosomal genesR01GM080415 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2007 to 2009
$903kHoward Hughes Medical InstituteNICHD NIH HHS U54 HD083092NIGMS NIH HHS R01 GM067858NIGMS NIH HHS R01 GM080415NIGMS NIH HHS RC4 GM096355NIH HHS P40 OD018537NIH HHS R24 OD022005NIMH NIH HHS R01 MH061876NINDS NIH HHS R01 NS061914
Abstract
Neurotransmission is a tightly regulated Ca
Indexed as
Citric Acid CycleSynaptic TransmissionAdenosine TriphosphateAnimalsCalciumDrosophila melanogasterDrosophila ProteinsIsocitrate DehydrogenaseKetoglutaric AcidsLarvaMitochondriaNeuromuscular JunctionPresynaptic TerminalsProtein BindingProtein DomainsSynaptic VesiclesAdenosine TriphosphateCalciumDrosophila ProteinsIsocitrate DehydrogenaseKetoglutaric AcidsSynaptotagminsalpha-ketoglutarateendocytosisexocytosissynaptotagminSyt1TCAtricarboxylic acid cycleαKG
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