ArticlePloS one2017
Correlations between specific patterns of spontaneous activity and stimulation efficiency in degenerated retina.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Resting-state electroretinography reveals pathological retinal oscillations in retinitis pigmentosa mice and patients.Nature communications · 2026Article
- Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types.The Journal of physiology · 2025Article
- Effects of taurine, brimonidine and betaxolol on oscillation modulation and stimulation efficiency in degenerated rd10 mouse retinas.Scientific reports · 2025Article
- Article
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- High amplitude pulses on the same charge condition efficiently elicit bipolar cell-mediated retinal ganglion cell responses in the degenerate retina.Biomedical engineering letters · 2023Article
- Bi-directional electrical recording and stimulation of the intact retina with a screen-printed soft probe: a feasibility study.Frontiers in neuroscience · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- DNA and RNA oxidative damage in the retina is associated with ganglion cell mitochondria.Scientific reports · 2022Article
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- In the Eye of the Storm: Bi-Directional Electrophysiological Investigation of the Intact Retina.Frontiers in neuroscience · 2022Article
- Development and in vitro validation of flexible intraretinal probes.Scientific reports · 2020Article
- Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10.Investigative ophthalmology & visual science · 2020Article
- Establishment and Characterization of a Unilateral UV-Induced Photoreceptor Degeneration Model in the C57Bl/6J Mouse.Translational vision science & technology · 2020Article
- Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses.Healthcare technology letters · 2020Article
- Toward a Bidirectional Communication Between Retinal Cells and a Prosthetic Device - A Proof of Concept.Frontiers in neuroscience · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal prostheses that are currently used to restore vision in patients suffering from retinal degeneration are not adjusted to the changes occurring during the remodeling process of the retina. Recent studies revealed abnormal rhythmic activity in the retina of genetic mouse models of retinitis pigmentosa. Here we describe this abnormal activity also in a pharmacologically-induced (MNU) mouse model of retinal degeneration. To investigate how this abnormal activity affects the excitability of retinal ganglion cells, we recorded the electrical activity from whole mounted retinas of rd10 mice and MNU-treated mice using a microelectrode array system and applied biphasic current pulses of different amplitude and duration to stimulate ganglion cells electrically. We show that the electrical stimulation efficiency is strongly reduced in degenerated retinas, in particular when abnormal activity such as oscillations and rhythmic firing of bursts of action potentials can be observed. Using a prestimulus pulse sequence, we could abolish rhythmic retinal activity. Under these conditions, the stimulation efficiency was enhanced in a few cases but not in the majority of tested cells. Nevertheless, this approach supports the idea that modified stimulation protocols could help to improve the efficiency of retinal prostheses in the future.
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