Evidence map›Paper›PMID 29281710›Full record

ArticlePloS one2017

Maternal influenza immunization in Malawi: Piloting a maternal influenza immunization program costing tool by examining a prospective program.

Clint Pecenka, Spy Munthali, Paul Chunga, Ann Levin, Win Morgan, Philipp Lambach, Niranjan Bhat, Kathleen M Neuzil, Justin R Ortiz, Raymond Hutubessy

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Costs of seasonal influenza vaccination in South Africa.Influenza and other respiratory viruses · 2022
    Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Clint PecenkaCenter for Vaccine Innovation and Access, PATH, Seattle, Washington, United States of America.
Spy MunthaliChancellor's College, Zomba, Malawi.
Paul ChungaMinistry of Health, Lilongwe, Malawi.
Ann LevinLevin and Morgan, Washington, DC, United States of America.
Win MorganLevin and Morgan, Washington, DC, United States of America.
Philipp LambachInitiative for Vaccine Research, World Health Organization, Geneva, Switzerland.
Niranjan BhatCenter for Vaccine Innovation and Access, PATH, Seattle, Washington, United States of America.
Kathleen M NeuzilCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Justin R OrtizInitiative for Vaccine Research, World Health Organization, Geneva, Switzerland.
Raymond HutubessyInitiative for Vaccine Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-9286-5065
World Health Organization · CHMorgan, Lewis & Bockius (United States) · USProgram for Appropriate Technology in Health · USMinistry of Health · MWUniversity of Malawi · MWUniversity of Maryland, Baltimore · US

Funding

NCEZID CDC HHS U50 CK000431World Health Organization 001
6 · The paper itself

Abstract

backgroundThis costing study in Malawi is a first evaluation of a Maternal Influenza Immunization Program Costing Tool (Costing Tool) for maternal immunization. The tool was designed to help low- and middle-income countries plan for maternal influenza immunization programs that differ from infant vaccination programs because of differences in the target population and potential differences in delivery strategy or venue.

methodsThis analysis examines the incremental costs of a prospective seasonal maternal influenza immunization program that is added to a successful routine childhood immunization and antenatal care program. The Costing Tool estimates financial and economic costs for different vaccine delivery scenarios for each of the major components of the expanded immunization program.

resultsIn our base scenario, which specifies a donated single dose pre-filled vaccine formulation, the total financial cost of a program that would reach 2.3 million women is approximately $1.2 million over five years. The economic cost of the program, including the donated vaccine, is $10.4 million over the same period. The financial and economic costs per immunized pregnancy are $0.52 and $4.58, respectively. Other scenarios examine lower vaccine uptake, reaching 1.2 million women, and a vaccine purchased at $2.80 per dose with an alternative presentation.

conclusionThis study estimates the financial and economic costs associated with a prospective maternal influenza immunization program in a low-income country. In some scenarios, the incremental delivery cost of a maternal influenza immunization program may be as low as some estimates of childhood vaccination programs, assuming the routine childhood immunization and antenatal care systems are capable of serving as the platform for an additional vaccination program. However, purchasing influenza vaccines at the prices assumed in this analysis, instead of having them donated, is likely to be challenging for lower-income countries. This result should be considered as a starting point to understanding the costs of maternal immunization programs in low- and middle-income countries.

Indexed as

FemaleHumansImmunization ProgramsInfluenza VaccinesMalawiPilot ProjectsPregnancyProspective StudiesInfluenza Vaccines

Identifiers

PMID29281710
PMCPMC5744963
OpenAlexW2779649691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.