ArticlePloS one2017
A genome-wide study to identify genes responsible for oviduct development in chickens.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genetic Basis of Egg Production in Baicheng-You Chickens: A Genome-Wide Association Study.Animals : an open access journal from MDPI · 2025Article
- Leveraging genome-wide association analyses with chip and imputed data emerges potential pleiotropic region for four duck growth traits.Scientific reports · 2025Article
- Integration of GWAS and transcriptomic analyses reveal candidate genes for duck gonadal development during puberty onset.BMC genomics · 2024Article
- Elucidation of the genetic determination of clutch traits in Chinese local chickens of the Laiwu Black breed.BMC genomics · 2023Article
- The genomic characteristics affect phenotypic diversity from the perspective of genetic improvement of economic traits.iScience · 2023Article
- Disentangling clustering configuration intricacies for divergently selected chicken breeds.Scientific reports · 2023Article
- Article
- Effect of very low-protein diets supplemented with branched-chain amino acids on energy balance, plasma metabolomics and fecal microbiome of pigs.Scientific reports · 2020Article
- A Map of Racial and Ethnic Disparities in Influenza Vaccine Uptake in the Medicare Fee-for-Service Program.Advances in therapy · 2020Article
- Genetic architecture and candidate genes detected for chicken internal organ weight with a 600 K single nucleotide polymorphism array.Asian-Australasian journal of animal sciences · 2019Article
- Gene expression variation and parental allele inheritance in a Xiphophorus interspecies hybridization model.PLoS genetics · 2018Article
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11 authors.
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Abstract
Molecular genetic tools provide a method for improving the breeding selection of chickens (Gallus gallus). Although some studies have identified genes affecting egg quality, little is known about the genes responsible for oviduct development. To address this issue, here we used a genome-wide association (GWA) study to detect genes or genomic regions that are related to oviduct development in a chicken F2 resource population by employing high-density 600 K single-nucleotide polymorphism (SNP) arrays. For oviduct length and weight, which exhibited moderate heritability estimates of 0.35 and 0.39, respectively, chromosome 1 (GGA1) explained 9.45% of the genetic variance, while GGA4 to GGA8 and GGA11 explained over 1% of the variance. Independent univariate genome-wide screens for oviduct length and weight detected 69 significant SNPs on GGA1 and 49 suggestive SNPs on GGA1, GGA4, and GGA8. One hundred and fourteen suggestive SNPs were associated with oviduct length, while 73 SNPs were associated with oviduct weight. The significant genomic regions affecting oviduct weight ranged from 167.79-174.29 Mb on GGA1, 73.16-75.70 Mb on GGA4, and 4.88-4.92 Mb on GGA8. The genes CKAP2, CCKAR, NCAPG, IGFBP3, and GORAB were shown to have potential roles in oviduct development. These genes are involved in cell survival, appetite, and growth control. Our results represent the first GWA analysis of genes controlling oviduct weight and length. The identification of genomic loci and potential candidate genes affecting oviduct development greatly increase our understanding of the genetic basis underlying oviduct development, which could have an impact on the selection of egg quality.
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