Evidence map›Paper›PMID 29281666›Full record

ArticlePloS one2017

Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.

Eleanor L Watts, Paul N Appleby, Demetrius Albanes, Amanda Black, June M Chan, Chu Chen, Piera M Cirillo, Barbara A Cohn, Michael B Cook, Jenny L Donovan and 45 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Reproductive axis ageing and fertility in men.Reviews in endocrine & metabolic disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Eleanor L WattsCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9229-2589
Paul N ApplebyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, United States of America.
Amanda BlackDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, United States of America.
June M ChanDepartment of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, United States of America.
Chu ChenProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Piera M CirilloChild Health and Development Studies, Public Health Institute, Berkeley, CA, United States of America.
Barbara A CohnChild Health and Development Studies, Public Health Institute, Berkeley, CA, United States of America.
Michael B CookDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, United States of America.
Jenny L DonovanSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Luigi FerrucciIntramural Research Program, National Institute on Aging, Bethesda, MD, United States of America.
Cedric F GarlandDepartment of Family Medicine and Public Health, University of California, San Diego, CA, United States of America.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Laurel A HabelDivision of Research, Kaiser Permanente Northern California, Oakland, CA, United States of America.
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Jeff M P HollySchool of Clinical Sciences, Faculty of Health Science, University of Bristol, Bristol, United Kingdom.
Robert N HooverDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, United States of America.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Paul KnektDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Laurence N KolonelUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, United States of America.
Tatsuhiko KuboDepartment of Public Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
Loïc Le MarchandUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, United States of America.
Tapio LuostarinenFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Robert J MacInnisCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Hanna O MäenpääDepartment of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
Satu MännistöDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
E Jeffrey MetterDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN, United States of America.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Abraham M Y NomuraJapan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu, HI, United States of America.
Steven E OliverDepartment of Health Sciences, University of York, York, United Kingdom.
J Kellogg ParsonsDivision of Urologic Oncology, University of California San Diego Moores Cancer Center, San Diego, CA, United States of America.
Petra H PeetersDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States of America.
Elio RiboliSchool of Public Health, Imperial College London, London, United Kingdom.
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
Sabina RinaldiBiomarkers Group, International Agency for Research on Cancer, Lyon, France.
Harri RissanenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Norie SawadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Catherine A SchaeferDivision of Research, Kaiser Permanente Northern California, Oakland, CA, United States of America.
Jeannette M SchenkCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Frank Z StanczykDivision of Reproductive Endocrinology and Infertility, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.
Meir StampferDepartments of Nutrition and Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, MA, United States of America.
Pär StattinDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Ulf-Håkan StenmanDepartment of Clinical Chemistry, Medicum, University of Helsinki, Helsinki, Finland.
Anne TjønnelandDepartment of Diet, Genes and Environment, The Danish Cancer Society Research Center, Copenhagen, Denmark.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Ian M ThompsonCHRISTUS Medical Center Hospital, San Antonio, TX, United States of America.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Lars VattenDepartment of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Alice S WhittemoreDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, United States of America.
Regina G ZieglerDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, United States of America.
Naomi E AllenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Funding

Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8M
PLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
Molecular Link Between Metabolic Syndrome and Prostate CancerR01CA131945 · NCI · DANA-FARBER CANCER INST · PI LODA, MASSIMO · 2008 to 2018
$4.0M
Energy Balance-Related Hormones & Prostate Cancer Incidence & ProgressionR01CA133891 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GIOVANNUCCI, EDWARD · 2008 to 2012
$3.3M
Growth Factors and Lethal Prostate Cancer SignatureR01CA141298 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI STAMPFER, MEIR · 2010 to 2013
$2.2M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
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Cancer Research UK 16491Cancer Research UK 19170NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS P01 CA055075NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA131945NCI NIH HHS R01 CA133891NCI NIH HHS R01 CA141298NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182883NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NICHD NIH HHS HHSN275201100020CWorld Health Organization 001
6 · The paper itself

Abstract

introductionSex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin.

methodsStatistical analyses of individual participant data from 12,330 male controls aged 25-85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.

resultsOlder age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones.

conclusionCirculating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.

Indexed as

AnthropometryBehaviorDatasets as TopicSocial ClassAdultGonadal Steroid HormonesHumansMaleYoung AdultGonadal Steroid Hormones

Identifiers

PMID29281666
PMCPMC5744924

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.