Evidence map›Paper›PMID 29281558›Full record

ArticleCancer biology & therapy2018

Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma.

Yan Guo, Yuji Ma, Xuanhao Hu, Rongbo Song, Li Zhu, Ming Zhong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan Guoa Department of Central Laboratory , School of Stomatology, China Medical University , Shenyang , Liaoning , China.
Yuji Maa Department of Central Laboratory , School of Stomatology, China Medical University , Shenyang , Liaoning , China.
Xuanhao Hud Department of Neurobiology , China Medical University , Shenyang , Liaoning , China.
Rongbo Songa Department of Central Laboratory , School of Stomatology, China Medical University , Shenyang , Liaoning , China.
Li Zhua Department of Central Laboratory , School of Stomatology, China Medical University , Shenyang , Liaoning , China.
Ming Zhonga Department of Central Laboratory , School of Stomatology, China Medical University , Shenyang , Liaoning , China.
China Medical University · CNShenyang Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most aggressive and lethal malignancies affecting the head and neck region with a general 5-year survival rate about 50%. Long non-coding RNAs (lncRNAs) are believed to participate in diverse biological processes and are emerging as convenient and minimally invasive diagnostic/prognostic/therapeutic markers. The aim of this study was to explore CEBPA-AS1 role and mechanism in OSCC tumorigenesis. In this study, CEBPA-AS1 localized in the cytoplasm and the peri-nuclear cellular compartment functioning as a potential oncogene up-regulated in OSCC was correlated with poor differentiation, lymph node metastasis and high clinical stage, which made it considered to be a prognostic biomarker. Silence of CEBPA-AS1 inhibited OSCC cells proliferation and induced cells apoptosis, migration and invasion by targeting CEBPA and via a novel pathway CEBPA/Bcl2. Our findings provided the first evidence for the lncRNA CEBPA-AS1 regulatory network in OSCC tumorigenesis, which might be helpful to improve the effects of clinical treatment in OSCC.

Indexed as

ApoptosisBiomarkers, TumorCarcinogenesisCarcinoma, Squamous CellCCAAT-Enhancer-Binding ProteinsCell Line, TumorCell ProliferationCytoplasmFemaleGene Expression Regulation, NeoplasticHumansKeratinocytesLymphatic MetastasisMaleMiddle AgedMouth MucosaBCL2 protein, humanBiomarkers, TumorCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanProto-Oncogene Proteins c-bcl-2RNA, Long NoncodingCEBPACEBPA-AS1LncRNAsOral squamous cell carcinoma

Identifiers

PMID29281558
PMCPMC5790341
OpenAlexW2776556286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.