Evidence map›Paper›PMID 29281126›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018

Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.

Anne L Schafer, Galateia J Kazakia, Eric Vittinghoff, Lygia Stewart, Stanley J Rogers, Tiffany Y Kim, Jonathan T Carter, Andrew M Posselt, Courtney Pasco, Dolores M Shoback and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04087096 (Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04087096 phase4completednot on this mapstarted 2020, after this paper: background citation

Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery

TypeinterventionalSponsorMassachusetts General HospitalRan2020 to 2024Enrolled36ConditionsBariatric Surgery Candidate, Bone LossArmsDenosumab, Placebo, Zoledronic Acid
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Changes in volumetric bone mineral density and bone quality after Roux-en-Y gastric bypass: A meta-analysis with meta-regression.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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  13. Effects of Glucagon-Like Peptide-1 receptor agonists on bone health in people living with obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Anne L SchaferDepartment of Medicine, University of California, San Francisco, CA, USA.
Galateia J KazakiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Lygia StewartDepartment of Surgery, University of California, San Francisco, CA, USA.
Stanley J RogersDepartment of Surgery, University of California, San Francisco, CA, USA.
Tiffany Y KimDepartment of Medicine, University of California, San Francisco, CA, USA.
Jonathan T CarterDepartment of Surgery, University of California, San Francisco, CA, USA.
Andrew M PosseltDepartment of Surgery, University of California, San Francisco, CA, USA.
Courtney PascoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Dolores M ShobackDepartment of Medicine, University of California, San Francisco, CA, USA.
Dennis M BlackDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco VA Health Care System · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
Effects of Sleeve Gastrectomy on Calcium Metabolism and the SkeletonR01DK107629 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SCHAFER, ANNE LOUISE · 2016 to 2020
$2.4M
Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass SurgeryR21DK112126 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SCHAFER, ANNE LOUISE · 2017 to 2018
$448k
Effects of Gastric Bypass Surgery on Calcium Metabolism and the SkeletonIK2CX000549 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI SCHAFER, ANNE LOUISE · 2011 to 2015
–
CSRD VA IK2 CX000549NCATS NIH HHS UL1 TR000004NIAMS NIH HHS P30 AR066262NIDDK NIH HHS R01 DK107629NIDDK NIH HHS R21 DK112126
6 · The paper itself

Abstract

Roux-en-Y gastric bypass (RYGB) surgery is a highly effective treatment for obesity but negatively affects the skeleton. Studies of skeletal effects have generally examined areal bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA), but DXA may be inaccurate in the setting of marked weight loss. Further, as a result of modestly sized samples of mostly premenopausal women and very few men, effects of RYGB by sex and menopausal status are unknown. We prospectively studied the effects of RYGB on skeletal health, including axial and appendicular volumetric BMD and appendicular bone microarchitecture and estimated strength. Obese adults (N = 48; 27 premenopausal and 11 postmenopausal women, 10 men) with mean ± SD body mass index (BMI) 44 ± 7 kg/m

Indexed as

AdultAgedBiomarkersBody CompositionBone and BonesBone DensityBone RemodelingDietFemaleGastric BypassHumansMiddle AgedOrgan SizePostmenopauseBiomarkersBARIATRIC SURGERYBIOCHEMICAL MARKERS OF BONE TURNOVERBONE MICROARCHITECTUREBONE MINERAL DENSITYGASTRIC BYPASS SURGERY

Identifiers

PMID29281126
PMCPMC6002877
OpenAlexW2780617250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.