ArticleThe Journal of infectious diseases2018
Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Metatranscriptomic profiling reveals pathogen and host response signatures of pediatric acute sinusitis and upper respiratory infection.Genome medicine · 2025Article
- Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections.Viruses · 2025Review
- Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection.Journal of clinical and translational science · 2025Article
- High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children.The Journal of experimental medicine · 2024Article
- A machine learning classifier using 33 host immune response mRNAs accurately distinguishes viral and non-viral acute respiratory illnesses in nasal swab samples.Genome medicine · 2023Article
- Respiratory viruses: New frontiers-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2023Article
- Curtailing virus-induced inflammation in respiratory infections: emerging strategies for therapeutic interventions.Frontiers in pharmacology · 2023Review
- Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study.The Lancet. Microbe · 2023Article
- A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity.Environmental research · 2022Article
- Novel Biomarkers Differentiating Viral from Bacterial Infection in Febrile Children: Future Perspectives for Management in Clinical Praxis.Children (Basel, Switzerland) · 2021Review
- Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics.The Journal of experimental medicine · 2021Article
- Dual RNA-Seq Enables Full-Genome Assembly of Measles Virus and Characterization of Host-Pathogen Interactions.Microorganisms · 2021Article
- Probing the early upper respiratory responses to SARS-CoV-2.Physiological reports · 2021Article
- Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate.Influenza and other respiratory viruses · 2021Article
- A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood.Science advances · 2021Article
- Magnitude and timing of the antiviral response determine SARS-CoV-2 replication early in infection.medRxiv : the preprint server for health sciences · 2021Article
- Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection.Frontiers in genetics · 2021Article
- Viral Coinfection and Nasal Cytokines in Children With Clinically Diagnosed Acute Sinusitis.Frontiers in pediatrics · 2021Article
- Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study.The Lancet. Microbe · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Background: Despite the high burden of respiratory infection and the importance of early and accurate diagnosis, there is no simple diagnostic test to rule in viral infection as a cause of respiratory symptoms. Methods: We performed RNA sequencing on human nasal epithelial cells following stimulation of the intracellular viral recognition receptor RIG-I. Next, we evaluated whether measuring identified host mRNAs and proteins from patient nasopharyngeal swabs could predict the presence of a respiratory virus in the sample. Results: Our first study showed that a signature of 3 mRNAs, CXCL10, IFIT2, and OASL, predicted respiratory virus detection with an accuracy of 97% (95% confidence interval [CI], 0.9-1.0), and identified proteins correlating with virus detection. In a second study, elevated CXCL11 or CXCL10 protein levels identified samples containing respiratory viruses, including viruses not on the initial test panel. Overall area under the curve (AUC) values were: CXCL11 AUC = 0.901 (95% CI, 0.86-0.94); CXCL10 AUC = 0.85 (95% CI, 0.80-0.91). Conclusions: Host antiviral mRNAs and single host proteins detectable using nasopharyngeal swabs accurately predict the presence of viral infection. This approach holds promise for developing rapid, cost-effective tests to improve management of patients with respiratory illnesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.