ArticleeLife2017
Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
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In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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0cells of the map it votes in
32citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
What it found
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.Nature cardiovascular research · 2026Article
- Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.Development (Cambridge, England) · 2026Article
- Role of eRNAs in Cardiovascular Diseases.Current cardiology reviews · 2026Review
- A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.Circulation · 2024Article
- The roles of long noncoding RNAs in atrial fibrillation.Non-coding RNA research · 2023Article
- The chromatin signatures of enhancers and their dynamic regulation.Nucleus (Austin, Tex.) · 2023Review
- Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.Nature cardiovascular research · 2023Article
- Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development.iScience · 2023Article
- Article
- Enhancer RNA (eRNA) in Human Diseases.International journal of molecular sciences · 2022Review
- Article
- Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis.International journal of molecular sciences · 2022Review
- Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction.Circulation · 2022Article
- Genomic enhancers in cardiac development and disease.Nature reviews. Cardiology · 2022Review
- Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.The Journal of clinical investigation · 2021Article
- A narrative review of non-coding RNAs in atrial fibrillation: potential therapeutic targets and molecular mechanisms.Annals of translational medicine · 2021Review
- Long noncoding RNA and atrial fibrillation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Transcriptional factors in calcium mishandling and atrial fibrillation development.Pflugers Archiv : European journal of physiology · 2021Review
- LincSNP 3.0: an updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements.Nucleic acids research · 2021Article
- Heart Enhancers: Development and Disease Control at a Distance.Frontiers in genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 2 countries.
Xinan H Yang *Department of Pediatrics, The University of Chicago, Chicago, United States.
Rangarajan D Nadadur *Department of Pediatrics, The University of Chicago, Chicago, United States.
Catharina Re HilveringHubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Uppsalalaan, Netherlands.
Valerio BianchiHubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Uppsalalaan, Netherlands.ORCID http://orcid.org/0000-0001-9025-7923
Michael WernerDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, United States.
Stefan R MazurekDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Margaret GadekDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Kaitlyn M ShenDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Joseph Aaron GoldmanDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.
Leonid TyanDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Jenna BekenyDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Johnathon M HallDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, United States.
Nutishia LeeDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.
Carlos Perez-CervantesDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Ozanna Burnicka-TurekDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Kenneth D PossDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.
Christopher R WeberDepartment of Pediatrics, The University of Chicago, Chicago, United States.
Wouter de LaatHubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen, University Medical Center Utrecht, Uppsalalaan, Netherlands.
Alexander J RuthenburgDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, United States.ORCID http://orcid.org/0000-0003-2709-4564
Ivan P MoskowitzDepartment of Pediatrics, The University of Chicago, Chicago, United States.ORCID https://orcid.org/0000-0003-0014-4963
University of Chicago · USDuke University · USRoyal Netherlands Academy of Arts and Sciences · NL
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MPREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0MMULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5MRegulation of Myocardial Regeneration in ZebrafishR01HL081674 · NHLBI · DUKE UNIVERSITY · PI POSS, KENNETH D · 2005 to 2019
$6.6MGenetic and Molecular Analysis of Mutants with Congenital Heart DefectsR01HL092153 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL · 2009 to 2017
$4.5MEtiology of Congenital Heart Disease in Down SyndromeR01HL124836 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, REEVES, ROGER H · 2014 to 2017
$2.7MBeagle-2S10OD018495 · OD · UNIVERSITY OF CHICAGO · PI FOSTER, IAN · 2014 to 2014
$2.0MFunctional Assays to Screen Genomic HitsR33HL123857 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, NOBREGA, MARCELO A. · 2016 to 2018
$1.5MDifferential enhancer transcription identifies cis-regulatory elements for diseaseR21LM012619 · NLM · UNIVERSITY OF CHICAGO · PI YANG, XINAN HOLLY · 2017 to 2018
$401kCHROMATIN REGULATORY EVENTS UNDERLYING HEART REGENERATIONF32HL120494 · NHLBI · DUKE UNIVERSITY · PI GOLDMAN, JOSEPH A. · 2013 to 2016
$174kDefining the TBX5-Dependent Gene Regulatory Networks of Atrial FibrillationF30HL131298 · NHLBI · UNIVERSITY OF CHICAGO · PI NADADUR, RANGARAJAN · 2016 to 2017
$98kNHLBI NIH HHS F30 HL131298NHLBI NIH HHS F32 HL120494NHLBI NIH HHS R01 HL081674NHLBI NIH HHS R01 HL092153NHLBI NIH HHS R01 HL124836NHLBI NIH HHS R33 HL123857NHLBI NIH HHS T32 HL007381NIGMS NIH HHS T32 GM007197NIGMS NIH HHS T32 GM007281NIH HHS S10 OD018495NLM NIH HHS R21 LM012619
Abstract
The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcription-factor-(TF)-dependence of ncRNA expression to define enhancers and enhancer-associated ncRNAs that are involved in a TF-dependent regulatory network. TBX5, a cardiac TF, regulates a network of cardiac channel genes to maintain cardiac rhythm. We deep sequenced wildtype and
Indexed as
Enhancer Elements, GeneticGene Regulatory NetworksTranscription, GeneticAnimalsHeartMicePeriodicityRNA, UntranslatedT-Box Domain ProteinsRNA, UntranslatedT-Box Domain ProteinsT-box transcription factor 5calciumchromosomesCis-regulatory elementenhancerevolutionary biologygenesgenomicslong noncoding RNA (lncRNA)mousenon-coding RNA (ncRNA)Tbx5Transcription factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.