Evidence map›Paper›PMID 29280050›Full record

ArticleNeuroinformatics2018

NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis.

Pawel J Markiewicz, Matthias J Ehrhardt, Kjell Erlandsson, Philip J Noonan, Anna Barnes, Jonathan M Schott, David Atkinson, Simon R Arridge, Brian F Hutton, Sebastien Ourselin

Abstract read
In one paragraph

Article in Neuroinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. PET Image Reconstruction Using Deep Diffusion Image Prior.IEEE transactions on medical imaging · 2026
    Article
  3. Article
  4. The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Micro-Networks for Robust MR-Guided Low Count PET Imaging.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  17. Article
  18. Article
  19. Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL-MRI: proof of concept.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  20. APPIAN: Automated Pipeline for PET Image Analysis.Frontiers in neuroinformatics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pawel J MarkiewiczTranslational Imaging Group, CMIC, Department of Medical Physics, Biomedical Engineering, University College London, London, UK. p.markiewicz@ucl.ac.uk.ORCID 0000-0002-3114-0773
Matthias J EhrhardtDepartment for Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Kjell ErlandssonInstitute of Nuclear Medicine, University College London, London, UK.
Philip J NoonanTranslational Imaging Group, CMIC, Department of Medical Physics, Biomedical Engineering, University College London, London, UK.
Anna BarnesInstitute of Nuclear Medicine, University College London, London, UK.
Jonathan M SchottDementia Research Centre, University College London, London, UK.
David AtkinsonCentre for Medical Imaging, University College London, London, UK.
Simon R ArridgeCentre for Medical Image Computing (CMIC), University College London, London, UK.
Brian F HuttonInstitute of Nuclear Medicine, University College London, London, UK.
Sebastien OurselinTranslational Imaging Group, CMIC, Department of Medical Physics, Biomedical Engineering, University College London, London, UK.

Funding

GLUTATHIONE IN BRAIN TUMOR RESISTANCE TO NITROSOUREASR29CA046410 · NCI · UNIVERSITY OF WASHINGTON · PI ALI-OSMAN, FRANCIS · 1988 to 1992
–
Medical Research Council CSUB19166Medical Research Council EP/K005278/1Medical Research Council MRC (MR/J01107X/1Medical Research Council MR/J01107X/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/N025792/1
6 · The paper itself

Abstract

We present a standalone, scalable and high-throughput software platform for PET image reconstruction and analysis. We focus on high fidelity modelling of the acquisition processes to provide high accuracy and precision quantitative imaging, especially for large axial field of view scanners. All the core routines are implemented using parallel computing available from within the Python package NiftyPET, enabling easy access, manipulation and visualisation of data at any processing stage. The pipeline of the platform starts from MR and raw PET input data and is divided into the following processing stages: (1) list-mode data processing; (2) accurate attenuation coefficient map generation; (3) detector normalisation; (4) exact forward and back projection between sinogram and image space; (5) estimation of reduced-variance random events; (6) high accuracy fully 3D estimation of scatter events; (7) voxel-based partial volume correction; (8) region- and voxel-level image analysis. We demonstrate the advantages of this platform using an amyloid brain scan where all the processing is executed from a single and uniform computational environment in Python. The high accuracy acquisition modelling is achieved through span-1 (no axial compression) ray tracing for true, random and scatter events. Furthermore, the platform offers uncertainty estimation of any image derived statistic to facilitate robust tracking of subtle physiological changes in longitudinal studies. The platform also supports the development of new reconstruction and analysis algorithms through restricting the axial field of view to any set of rings covering a region of interest and thus performing fully 3D reconstruction and corrections using real data significantly faster. All the software is available as open source with the accompanying wiki-page and test data.

Indexed as

Data AnalysisSoftwareBrainHigh-Throughput Screening AssaysHumansImage Processing, Computer-AssistedPositron-Emission TomographyBootstrapImage reconstructionNormalisationPartial volume correctionPETQuantificationRandom events estimationScatter correctionUncertainty

Identifiers

PMID29280050
PMCPMC5797201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.