Evidence map›Paper›PMID 29280047›Full record

ArticleInternational urology and nephrology2018

An evaluation of the protective effect of esomeprazole in an experimental model of renal ischemia-reperfusion.

Tayyar Alp Ozkan, Nihat Karakoyunlu, Reyhan Polat, Gülistan Sanem Sarıbaş, Nevzat Can Şener, Seyda Özdemir, Kevser Peker, Dilek Ünal, Can Tuygun

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In one paragraph

Article in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tayyar Alp OzkanDepartment of Urology, Kocaeli Derince Training and Research Hospital, Saglik Bilimleri University, Ibni Sina Blv 1, 41200, Derince, Kocaeli, Turkey. tayyaralp.ozkan@saglik.gov.tr.ORCID http://orcid.org/0000-0003-3115-3141
Nihat KarakoyunluDepartment of Urology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.
Reyhan PolatDepartment of Anesthesiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.
Gülistan Sanem SarıbaşDepartment of Histology and Embryology, Gazi University, Ankara, Turkey.
Nevzat Can ŞenerDepartment of Urology, Adana Numune Training and Research Hospital, Saglik Bilimleri University, Adana, Turkey.
Seyda ÖzdemirDepartment of Biochemistry, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.
Kevser PekerDepartment of Anesthesiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.
Dilek ÜnalDepartment of Anesthesiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.
Can TuygunDepartment of Urology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Saglik Bilimleri University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe ischemia and subsequent reperfusion (IR) which occurs in partial nephrectomy used in the treatment of renal tumors causes loss of parenchyma in the damaged kidney. The aim of this study is to evaluate, both biochemically and histologically, the efficacy of esomeprazole in an ischemia-reperfusion model in rat kidneys.

methodsThe rats were randomized into three groups of seven animals each, referred to as the sham, control, and PPI groups. In the sham group, only a laparotomy was performed. In the control group, following laparotomy the left renal artery was dissected and tied for 30-min ischemia. In the PPI group, a vascular route to the tail vein was opened, and 10 mg/kg esomeprazole was administered. After 1 h, the same procedures described for the control group were performed. All the animals were killed 24 h after the procedure. Biochemical analyses were applied for evaluation of oxidant and antioxidant agents in the blood and left kidney of each subject (oxidative markers: malondialdehyde, myeloperoxidase; antioxidant marker: superoxide dismutase). In the histological examination of the kidney tissues stained with hematoxylin-eosin, the TUNEL method was applied in the evaluation of apoptosis.

resultsNo statistically significant biochemical difference was determined in the blood and tissue samples. In the histological and apoptosis evaluations, a statistically significant difference was determined between the sham, control, and PPI groups. The median (IQR) values of the TUNEL-positive cells were counted as 1.50 (4) in the sham group, 11.50 (12) in the control group, and 6.00 (9) in the PPI group (p < 0.001).

conclusionsA protective effect of esomeprazole was confirmed in renal ischemia-reperfusion damage created in an experimental rat model.

Indexed as

KidneyReperfusion InjuryAnimalsApoptosisEnzyme InhibitorsEsomeprazoleKidney NeoplasmsMalondialdehydeModels, TheoreticalNephrectomyOxidative StressRatsSuperoxide DismutaseTreatment OutcomeEnzyme InhibitorsEsomeprazoleMalondialdehydeSuperoxide DismutaseEsomeprazoleIschemia–reperfusion injuryProton pump inhibitorsRat

Identifiers

PMID29280047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.