Trial reportAnnals of biomedical engineering2018
Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative.
Trial report in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Minimalist Footwear and Knee Joint Loading During Walking in Healthy Adults: A Systematic Review of Evidence for Osteoarthritis Prevention.Journal of functional morphology and kinesiology · 2026Review
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- Swin UNETR Segmentation with Automated Geometry Filtering for Biomechanical Modeling of Knee Joint Cartilage.Annals of biomedical engineering · 2025Article
- Medial unicompartmental knee arthroplasty wear prediction using a total knee joint finite element model.Frontiers in bioengineering and biotechnology · 2025Article
- The development, use, and challenges of electromechanical tissue stimulation systems.Artificial organs · 2024Review
- Integration of Swin UNETR and statistical shape modeling for a semi-automated segmentation of the knee and biomechanical modeling of articular cartilage.Scientific reports · 2024Article
- Article
- Cumulative knee adduction moment during jogging causes temporary medial meniscus extrusion in healthy volunteers.Journal of medical ultrasonics (2001) · 2023Article
- Tibiofemoral Cartilage Contact Pressures in Athletes During Landing: A Dynamic Finite Element Study.Journal of biomechanical engineering · 2021Article
- Model for in-vivo estimation of stiffness of tibiofemoral joint using MR imaging and FEM analysis.Journal of translational medicine · 2021Article
- Cartilage tissue engineering for obesity-induced osteoarthritis: Physiology, challenges, and future prospects.Journal of orthopaedic translation · 2021Review
- Using Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- The biomechanical changes of load distribution with longitudinal tears of meniscal horns on knee joint: a finite element analysis.Journal of orthopaedic surgery and research · 2019Article
- Comparison between kinetic and kinetic-kinematic driven knee joint finite element models.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Evaluation of the subject-specific biomechanical effects of obesity on the progression of OA is challenging. The aim of this study was to create 3D MRI-based finite element models of the knee joints of seven obese subjects, who had developed OA at 4-year follow-up, and of seven normal weight subjects, who had not developed OA at 4-year follow-up, to test the sensitivity of cumulative maximum principal stresses in cartilage in quantitative risk evaluation of the initiation and progression of knee OA. Volumes of elements with cumulative stresses over 5 MPa in tibial cartilage were significantly (p < 0.05) larger in obese subjects as compared to normal weight subjects. Locations of high peak cumulative stresses at the baseline in most of the obese subjects showed a good agreement with the locations of the cartilage loss and MRI scoring at follow-up. Simulated weight loss (to body mass index 24 kg/m
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.