Evidence map›Paper›PMID 29280004›Full record

ArticleThe AAPS journal2017

The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.

Melanie A Felmlee, Bridget L Morse, Kristin E Follman, Marilyn E Morris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The AAPS journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melanie A FelmleeDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, 14214, USA. mfelmlee@pacific.edu.
Bridget L MorseDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, 14214, USA.
Kristin E FollmanDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, 14214, USA.
Marilyn E MorrisDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, 14214, USA.
University at Buffalo, State University of New York · US

Funding

Gamma-Hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment StrategiesR01DA023223 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MORRIS, MARILYN E · 2008 to 2016
$3.0M
NIDA NIH HHS R01 DA023223
6 · The paper itself

Abstract

The drug of abuse γ-hydroxybutyric acid (GHB) demonstrates complex toxicokinetics with dose-dependent metabolic and renal clearance. GHB is a substrate of monocarboxylate transporters (MCTs) which are responsible for the saturable renal reabsorption of GHB. MCT expression is observed in many tissues and therefore may impact the tissue distribution of GHB. The objective of the present study was to evaluate the tissue distribution kinetics of GHB at supratherapeutic doses. GHB (400, 600, and 800 mg/kg iv) or GHB 600 mg/kg plus L-lactate (330 mg/kg iv bolus followed by 121 mg/kg/h infusion) was administered to rats and blood and tissues were collected for up to 330 min post-dose. K

Indexed as

Administration, IntravenousAnimalsDrug OverdoseHydroxybutyratesIllicit DrugsMaleModels, AnimalMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersMuscle ProteinsRatsRats, Sprague-DawleySymportersTissue DistributionToxicokinetics4-hydroxybutyric acidHydroxybutyratesIllicit DrugsMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersMuscle ProteinsSlc16a3 protein, ratSymportersGamma-hydroxybutyric acidMonocarboxylate transportersToxicokinetics

Identifiers

PMID29280004
PMCPMC6467065
OpenAlexW2776653347

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.