Evidence map›Paper›PMID 29279967›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2018

NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.

Nadia M J Rupniak, Mary Katofiasc, Lesley Marson, Karl B Thor

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Recent Developments in On-Demand Voiding Therapies.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  2. [LysJournal of basic and clinical physiology and pharmacology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Colorectal and cardiovascular effects of [LysNaunyn-Schmiedeberg's archives of pharmacology · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nadia M J RupniakDignify Therapeutics LLC, P.O. Box 13169, 2 Davis Drive, Research Triangle Park, Durham, NC, 27709, USA. nrupniak@dignifytherapeutics.com.
Mary KatofiascDignify Therapeutics LLC, P.O. Box 13169, 2 Davis Drive, Research Triangle Park, Durham, NC, 27709, USA.
Lesley MarsonDignify Therapeutics LLC, P.O. Box 13169, 2 Davis Drive, Research Triangle Park, Durham, NC, 27709, USA.
Karl B ThorDignify Therapeutics LLC, P.O. Box 13169, 2 Davis Drive, Research Triangle Park, Durham, NC, 27709, USA.
Dignify Therapeutics (United States) · USTriangle · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tachykinin NK2 receptor (NK2R) agonists have potential to alleviate clinical conditions associated with bladder and gastrointestinal under activity. The effects of agonists with differing selectivity for NK2R over NK1Rs on colorectal, bladder, and cardiovascular function were examined in anesthetized dogs. Intravenous (IV) administration of NKA, LMN-NKA ([Lys

Indexed as

AnesthesiaAnimalsArterial PressureColonDogsFemaleHeart RateIndolesMaleNeurokinin-1 Receptor AntagonistsNeurokinin APiperidinesReceptors, Neurokinin-1Receptors, Neurokinin-2Urinary Bladder3-(2-methoxybenzylamino)-2-phenylpiperidineGR 159897IndolesNeurokinin-1 Receptor AntagonistsNeurokinin APiperidinesReceptors, Neurokinin-1Receptors, Neurokinin-2Colorectal pressureHypotensionTachykinin NK2 receptorVoiding efficiency

Identifiers

PMID29279967
OpenAlexW2778624974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.