Evidence map›Paper›PMID 29279858›Full record

ArticleeNeuro

Unsupervised Network Analysis of the Plastic Supraoptic Nucleus Transcriptome Predicts Caprin2 Regulatory Interactions.

Su-Yi Loh, Thomas Jahans-Price, Michael P Greenwood, Mingkwan Greenwood, See-Ziau Hoe, Agnieszka Konopacka, Colin Campbell, David Murphy, Charles C T Hindmarch

Open access · goldAbstract readValidation Study
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Su-Yi LohDepartment of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-7276-8938
Thomas Jahans-PriceSchool of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom.
Michael P GreenwoodSchool of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom.
Mingkwan GreenwoodSchool of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom.
See-Ziau HoeDepartment of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Agnieszka KonopackaSchool of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom.
Colin CampbellDepartment of Engineering Mathematics, University of Bristol, Bristol BS8 1UB, United Kingdom.ORCID 0000-0002-4775-9802
David MurphyDepartment of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-2946-0353
Charles C T HindmarchDepartment of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-6036-1292
University of Bristol · GBUniversity of Malaya · MYQueen's University · CA

Funding

Biotechnology and Biological Sciences Research Council BB/G006156/1Biotechnology and Biological Sciences Research Council BB/J005452/1Biotechnology and Biological Sciences Research Council BB/J015415/1British Heart Foundation RG/11/28714British Heart Foundation RG/11/6/28714Medical Research Council G0700954Medical Research Council MR/N022807/1Wellcome TrustWellcome Trust 097822/Z/11/Z
6 · The paper itself

Abstract

The supraoptic nucleus (SON) is a group of neurons in the hypothalamus responsible for the synthesis and secretion of the peptide hormones vasopressin and oxytocin. Following physiological cues, such as dehydration, salt-loading and lactation, the SON undergoes a function related plasticity that we have previously described in the rat at the transcriptome level. Using the unsupervised graphical lasso (Glasso) algorithm, we reconstructed a putative network from 500 plastic SON genes in which genes are the nodes and the edges are the inferred interactions. The most active nodal gene identified within the network was

Indexed as

TranscriptomeUnsupervised Machine LearningAnimalsComputational BiologyData MiningFemaleGene Expression RegulationMaleMicroarray AnalysisPC12 CellsRatsReal-Time Polymerase Chain ReactionRNA-Binding ProteinsRNA, MessengerSupraoptic NucleusCaprin2 protein, ratRNA-Binding ProteinsRNA, MessengerCaprin2functional plasticitygene networkGlassosupraoptic nucleustranscriptome

Identifiers

PMID29279858
PMCPMC5738864
OpenAlexW2773997135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.